In News:

Researchers at IIT Bombay, led by Viren Menezes from the Department of Aerospace Engineering, have developed a shockwave-based, needle-free syringe to deliver drugs painlessly and safely. The research was published in the Journal of Biomedical Materials and Devices.

Key Features of Shock Syringe:

• Unlike traditional syringes, the shock syringe uses high-energy shockwaves (traveling faster than the speed of sound) to deliver drugs, without the need for needles.
• The device is designed to reduce pain, tissue damage, and infection risk.
• The shock syringe aims to eliminate the discomfort and fear associated with needles.

How the Shock Syringe Works:

• The shock syringe is slightly longer than a ballpoint pen and contains a micro shock tube with three sections: driver, driven, and drug holder.
• Pressurized nitrogen gas is applied to the driver section, which creates a microjet of liquid drug. The microjet travels at speeds nearly twice as fast as a commercial airplane.
• The drug is then delivered through the nozzle of the syringe, penetrating the skin rapidly and gently.

Design Considerations:

• The syringe's nozzle has an opening of 125 μm (approximately the width of a human hair), ensuring a balance between precision and speed.
• Continuous monitoring of pressure ensures safe and effective drug delivery with minimal skin damage.

Testing and Results:

• Lab tests were conducted on rats, injecting three types of drugs:
  • Anaesthetics (Ketamine-Xylazine): Shock syringe produced similar results to needles in terms of effect onset and duration.
  • Viscous drugs (e.g., Terbinafine): The shock syringe outperformed needles, delivering the drug more deeply into the skin layers.
  • Insulin for diabetic rats: The shock syringe lowered blood sugar levels more effectively and sustained the effect for a longer period.
• The skin analysis revealed less damage and inflammation with the shock syringe compared to traditional needles.

Advantages:

• Painless drug delivery: Patients experience little to no discomfort.
• Reduced tissue damage: The shock syringe causes less skin trauma and inflammation.
• Faster healing: Wounds from the injection heal quicker compared to traditional needles.
• Better drug absorption: Especially for viscous drugs, the shock syringe delivers more efficient and deeper drug penetration.

Potential Applications:

• The shock syringe could revolutionize immunization drives, making vaccinations faster and more efficient.
• It could significantly reduce the risk of bloodborne diseases caused by needle-stick injuries.
• The device is designed to perform over 1,000 injections, ensuring cost-effectiveness and reliability with minimal nozzle replacements.

Future Prospects:

• While promising, the future of shock syringes in clinical use depends on:
  • Further innovation for human use.
  • Obtaining regulatory approval.
  • Ensuring the device’s affordability and accessibility.