Why is it in the News?

The Kitum cave in Mount Elgon National Park, Kenya, is known as the world's deadliest cave which may have some really dangerous viruses inside, like Ebola and Marburg.

What is Marburg Virus Disease (MVD)?

• Marburg virus disease (MVD), formerly known as Marburg hemorrhagic fever, is a severe, often fatal illness in humans.
• It affects both people and non-human primates.
• Marburg and Ebola viruses are both members of the Filoviridae family (filovirus).
• Though caused by different viruses, the two diseases are clinically similar.
  • Both diseases are rare and can cause outbreaks with high fatality rates.
  • The average MVD case fatality rate is around 50%.
• Rousettus aegyptiacus, fruit bats of the Pteropodidae family, are considered to be natural hosts of the Marburg virus.

Transmission:

• Human infection with MVD typically occurs after prolonged exposure to Rousettus bats inhabiting mines or caves.
• The virus can then spread through human-to-human transmission via direct contact with infected bodily fluids, contaminated materials, or broken skin and mucous membranes.

Symptoms:

• After an incubation period of 2-21 days, symptoms arise abruptly, including fever, chills, headache, and muscle pain.
• A maculopapular rash may appear around day five, most visible on the chest, back, and stomach.
• Other symptoms, such as nausea, vomiting, chest pain, sore throat, abdominal pain, and diarrhea, can manifest, with severity increasing to potentially include jaundice, organ dysfunction, severe weight loss, delirium, and massive hemorrhaging.
• The average MVD case fatality rate is around 50%, varying between 24% and 88% in past outbreaks.

Treatment:

• There is currently no specific treatment for MVD, but early supportive care involving rehydration and symptom management improves survival rates.

Viral Hemorrhagic Fevers (VHFs):

• Viral Hemorrhagic Fever (VHFs) is a group of diseases caused by several distinct families of viruses that affect multiple organ systems in the body.
• These illnesses range from mild to severe and life-threatening, with many having no known cure or vaccine.
• VHFs negatively impact the cardiovascular system and reduce overall bodily function.