Why in the News?

Over the past two decades, as genome sequencing technologies have become increasingly accessible, scientists have made significant strides in understanding the applications of Cell-free DNA.

Regarding Cell-free DNA:

• In the human body, a significant portion of the DNA in the genome is safely enclosed within cells, safeguarded by specific proteins to prevent degradation.
• However, in various circumstances, certain DNA fragments are liberated from their confines and can be found outside the cells, circulating in body fluids.
• These minute fragments of nucleic acids are commonly referred to as cell-free DNA (cfDNA).

How Cell-free DNA is generated/released?

• The generation and release of Cell-free DNA (cfDNA) can occur through various mechanisms.
• One such process is when a cell undergoes cell death, leading to the degradation of nucleic acids and subsequent release of cfDNA.
• The degradation of cfDNA is influenced by a diverse set of processes, resulting in variations in the amount, size, and origin of cfDNA.
• Furthermore, this release of cfDNA can be associated with different biological processes, including those essential for normal development, the progression of certain cancers, and various other diseases.
•  The generation and release of cfDNA can be triggered by a range of situations and processes, making it a versatile biomarker with potential implications in various health conditions.

Applications of Cell-free DNA (cfDNA):

• One of the most prevalent uses of cfDNA is in non-invasive prenatal testing, where it aids in screening fetuses for specific chromosomal abnormalities.
• Also, cfDNA serves as a valuable tool for comprehending human diseases and leveraging this knowledge to enhance diagnosis, monitoring, and prognosis.
• cfDNA plays a crucial role in understanding the rejection of transplanted organs by the body.
• It shows promise as a potential biomarker for various neurological disorders, including Alzheimer's disease, neuronal tumors, stroke, and traumatic brain injury.