In News:

The Anusandhan National Research Foundation (ANRF) has launched the Partnerships for Accelerated Innovation and Research (PAIR) program to significantly boost research and innovation across Indian universities, especially those with limited research infrastructure. The program is designed to bring about a transformative change in India's academic research ecosystem, aligning with the broader goals of the National Education Policy (NEP) 2020.

Key Details:

• Launch Date: November 2024
• Ministry/Department: Department of Science and Technology (DST)
• Objective:
  • To elevate research capabilities in universities that have limited resources by pairing them with well-established, top-tier institutions.
  • To foster collaborations that can help these emerging universities enhance their research quality, drive innovation, and make significant, globally competitive research contributions.
• Operational Model: Hub-and-Spoke Framework
  • Hub Institutions: These are well-established, top-tier institutions that will serve as mentors to less-researched universities. The hubs will be selected from:
    • The top 25 institutions in the National Institutional Ranking Framework (NIRF).
    • Institutions of National Importance ranked in the top 50 NIRF.
  • Spoke Institutions: These are emerging universities or institutions with limited research infrastructure. These will include:
    • Central and State Public Universities ranked within the top 200 NIRF Overall.
    • Top 100 NIRF University/State Public Universities.
    • Select NITs and IIITs.
• Funding:
  • The program has a budget allocation of up to ?100 crore per PAIR network.
  • Distribution of Funds:
    • 30% for the Hub institution.
    • 70% for the Spoke institutions.
  • Private Institutions serving as hubs will need to contribute 25% of their allocated budget.
• Mentorship & Research Focus:
  • Hubs will provide mentorship to spoke institutions, guiding them in various aspects of research such as access to resources, advanced infrastructure, and best practices.
  • The collaboration is expected to enhance research capabilities, foster innovation, and encourage the development of collaborative networks across institutions.
• Regional Diversity & Inclusion:
  • The program ensures regional diversity, with at least one spoke institution located outside the hub's state.
  • It also allows the inclusion of one promising university from Category III institutions that may not meet the eligibility criteria but show potential for growth in research.
• Phase-wise Rollout:
  • The first phase will focus on institutions ranked within the top 25 NIRF and Institutions of National Importance.
  • Future phases will expand the scope, allowing more universities and institutions to participate.
• Goals Aligned with NEP 2020:
  • Fostering Research Excellence: By partnering top institutions with emerging ones, PAIR seeks to improve the quality of research in India’s higher education sector.
  • Promoting Regional Diversity: Ensuring a geographically diverse set of institutions participate in the research ecosystem.
  • Strengthening Innovation: Helping universities in less-researched areas to compete on an international level, particularly in cutting-edge and impactful research.
• Program Implementation:
• Prospective Program Directors from eligible Hub institutions are invited to apply online for the program at ANRF PAIR Application Portal.

About ANRF:

• ANRF was established under the ANRF Act 2023 as an apex body to provide strategic direction for scientific research in India.
• With the formation of ANRF, the Science and Engineering Research Board (SERB), previously established under an act of Parliament in 2008, has been subsumed into ANRF.

In News:

• Cambodia saw a resurgence of H5N1 avian influenza cases after over 10 years of no human infections.
• From February 2023 to August 2024, 16 human cases were reported, with 3 deaths caused by the A/H5 clade 2.3.2.1c virus.
• Notably, 14 of these cases were caused by a novel reassortant virus, involving a mixture of clade 2.3.2.1c and clade 2.3.4.4b gene segments.

Key Points:

• Reassortment of the Virus:
  • The reassortment between clades 2.3.2.1c (Southeast Asia) and 2.3.4.4b (global spread) has created a new strain.
  • This reassortant virus is responsible for the second wave of infections in humans, starting in October 2023.
• Zoonotic Transmission:
  • Investigations confirmed that direct contact with sick poultry or bird droppings was the primary source of human infections.
  • There have been no reported cases of human-to-human transmission.
  • The novel reassortant virus appears to have replaced the 2.3.2.1c strain in Cambodian poultry.
• Geographic Spread and Spillovers:
  • Clade 2.3.2.1c was first reported in Cambodian poultry in March 2014. It continued to circulate in both poultry and wild birds.
  • Clade 2.3.4.4b viruses began circulating in Cambodian live bird markets by 2021, co-existing with clade 2.3.2.1c.
  • There were two key spillovers to humans:
    • The first spillover in February 2023, associated with clade 2.3.2.1c, involved two related individuals, with one death.
    • The second spillover, beginning in October 2023, involved the novel reassortant virus.
• Genetic Analysis and Mutation Concerns:
  • Genetic sequencing showed significant changes in the hemagglutinin (HA) gene of viruses from human cases, indicating a shift from older local strains to newer sublineages.
  • The PB2 627K mutation in the novel reassortant is concerning, as it is linked to increased mammalian adaptation and the potential for airborne transmission, particularly in mammals like ferrets.
  • This mutation raises concerns about the virus’s ability to adapt to humans or other mammals.
• Environmental and Epidemiological Factors:
  • The reassortment is believed to have been facilitated by:
    • High-density poultry farming.
    • Wild bird migration.
    • Cross-border poultry trade in Southeast Asia.
  • These factors heighten the risk of zoonotic transmission, emphasizing the need for continued vigilance in the region.
• Surveillance and Response:
  • One Health investigations linked human cases to infected poultry, highlighting the importance of rapid response through whole genome sequencing.
  • The ongoing surveillance is critical, as the novel reassortant strain has already replaced clade 2.3.2.1c in Cambodian poultry.
• Public Health Recommendations:
  • There is an urgent need to strengthen sustained surveillance of avian influenza in both poultry and wild birds, particularly in Southeast Asia.
  • Public health strategies should focus on:
    • Reducing human exposure to infected poultry.
    • Promoting safe poultry handling practices.
    • Encouraging early healthcare-seeking behavior in individuals with potential symptoms.

In News:

• The 3rd Indian Space Conclave, held in New Delhi, was a significant event for India's growing role in global space exploration and strategic partnerships.
• Organized by the Indian Space Association (ISPA), the conclave brought together key stakeholders from the government, industry, academia, and space agencies to discuss India’s space ambitions and the transformative role of space technologies.

Key Highlights:

Satcom as a Transformative Force for Digital India

• Emphasis on Satellite Communication (Satcom) is more than a mere tool—it's a transformative force driving Digital India by connecting every household, village, and remote area of the country.
• Satcom has a wide array of applications that extend across essential sectors such as telecommunications, disaster management, healthcare, education, and agriculture, particularly in underserved regions.

Indo-EU Space Collaboration

• The event also showcased India’s growing space partnerships, particularly with the European Union (EU). The EU Ambassador recognized India as a dynamic space power and highlighted shared goals in Earth observation, space security, and human spaceflight.
• Proposed joint initiatives include training programs, collaborative research, and satellite missions, such as the Proba-3 satellite launch by ISRO, focusing on observing the Sun.
• India’s trustworthiness as a partner in space was underscored by its role in the successful launch of the Proba-1 and Proba-2 missions for the EU, with Proba-3 marking India’s third contribution to EU space exploration.

Space Startups and Innovation

• The rise of space-focused startups in India, spurred by the 2020 space sector reforms, was another key highlight. India now has over 300 space startups, contributing to both economic growth and innovation in the space industry.
• These reforms have helped curb brain drain, with many talented Indian professionals returning from global agencies like NASA to join the expanding Indian space ecosystem.

India’s Long-Term Space Goals

• The Indian space program has ambitious long-term goals, including:
  • Gaganyaan, India’s human spaceflight mission.
  • A crewed lunar landing by 2040.
  • The establishment of an Indian space station by 2035.
  • Plans for space tourism by 2040.
• These initiatives demonstrate India’s commitment to becoming a global leader in space exploration and technological innovation.

Space Sector Reforms (2020)

• The Space Sector Reforms 2020 were designed to increase the participation of private players in India’s space activities. The creation of agencies like the Indian National Space Promotion and Authorization Center (IN-SPACe) and the strengthening of New Space India Limited (NSIL) have been pivotal in boosting India’s global space market share.
• IN-SPACe serves as an autonomous body fostering industry, academia, and startups, while NSIL handles commercial activities and promotes high-tech space-related ventures.

India's First Mars and Moon Analog Mission

• ISRO's First Mars and Moon Analog Mission was inaugurated in Leh, Ladakh. This mission simulates the conditions of space habitats, specifically focusing on Mars and Moon environments.
• Ladakh's unique climate—high altitude, low oxygen levels, and extreme temperature fluctuations—makes it an ideal location for testing life support systems, space habitat technologies, and sustainable resource utilization.

Key Aspects of the Analog Mission:

• Life support systems like hydroponics (space farming) and standalone solar power systems to support sustainable food production and renewable energy in space habitats.
• Circadian lighting to simulate daylight cycles, maintaining astronaut health and well-being.
• The mission’s goal is to understand the psychological and operational challenges of living in isolation and extreme conditions, preparing India for future interplanetary exploration.

In News:

• ‘AntarikshaAbhyas – 2024’ is a three-day space exercise held from November 11-13, 2024, hosted by the Defence Space Agency (DSA), Headquarters Integrated Defence Staff.
• The exercise is the first of its kind and focuses on war-gaming the growing threats to space-based assets and services.

Objective of the Exercise:

• Enhance understanding of space-based assets and their operational dependencies.
• Identify vulnerabilities in military operations in case of denial or disruption of space services.
• Integrate India's space capabilities in military operations to secure national strategic objectives.

Participants:

• Defence Space Agency (DSA) and its allied units.
• Personnel from the Army, Navy, and Air Force.
• Specialist agencies under Headquarters Integrated Defence Staff, including:
  • Defence Cyber Agency (DCA)
  • Defence Intelligence Agency (DIA)
  • Strategic Forces Command (SFC)
• Representatives from ISRO (Indian Space Research Organisation) and DRDO (Defence Research & Development Organisation).

Focus Areas:

• Space-based asset and service operational dependency.
• Securing national interests in space through technological innovation and development.
• Assessing space service vulnerabilities and impacts on military operations.

In News:

Chinese rover helps find evidence of ancient Martian shoreline.

Mission Overview:

• Rover: Zhurong, part of China’s Tianwen-1 Mars exploration program.
• Mission Launch: Zhurong landed in 2021 in the Utopia Planitia region of Mars' northern hemisphere.
• Key Discovery: Evidence of an ancient ocean on Mars, suggesting a habitable past for the planet.

Key Findings:

• Geological Features Indicating a Coastline:
  • Data from Zhurong and orbiting spacecraft (Tianwen-1 Orbiter, NASA's Mars Reconnaissance Orbiter) revealed geological features such as troughs, sediment channels, and mud volcano formations, suggesting the existence of a Martian coastline.
  • Features indicate both shallow and deeper marine environments, supporting the idea of a past ocean.
• Age of the Ocean:
  • The ocean likely existed around 3.68 billion years ago, with its surface potentially frozen in a geologically short period.
  • The ocean is thought to have disappeared by 3.42 billion years ago.

Evolutionary Scenario of Mars:

• At the time of the ocean, Mars might have already begun transitioning away from a habitable planet, losing much of its atmosphere and becoming cold and dry.
• The ocean may have formed after Mars' climate began to change, suggesting that it was once more hospitable, possibly capable of supporting microbial life.

Implications for Life on Mars:

• The presence of water, a key ingredient for life, raises the possibility that Mars could have supported microbial life in its early history.
• When Mars had a thick, warm atmosphere, conditions might have been favorable for life, as microbial life would have been more likely to exist.

Significance of Zhurong's Contribution:

• Zhurong exceeded its original mission duration of three months, operating until May 2022, helping provide key data to understand Mars' ancient water history.
• The discovery adds to ongoing efforts to study the disappearance of water on Mars and its implications for the planet's habitability.

Future Exploration:

• Other studies, including seismic data from NASA’s InSight lander, suggest that liquid water might still exist deep beneath the Martian surface, hinting at the possibility of finding water in the planet's subsurface in the future.

In News:

• NTPC has achieved the first-ever synthesis of CO? (captured from flue gas) and hydrogen (produced via a PEM electrolyzer) into methanol at its Vindhyachal plant.
• This marks a significant step in carbon management technology, aimed at advancing sustainable fuel production.

About CO?-to-Methanol Conversion:

• Carbon Dioxide Capture:
  • CO? is captured from industrial sources, such as power plants, or directly from the atmosphere.
• Hydrogen Production:
  • Renewable energy sources like solar or wind power are used to produce hydrogen through water electrolysis.
• Methanol Synthesis:
  • The captured CO? is combined with hydrogen in the presence of a catalyst to produce methanol, typically under high pressure and temperature conditions.

Benefits of CO?-to-Methanol Conversion:

• Carbon Capture and Utilization (CCU):
  • This technology reduces the impact of CO? on the atmosphere by converting it into useful products.
• Renewable Fuel Source:
  • Methanol produced through this process can be used as a fuel for transportation, power generation, or as a feedstock for chemicals.
• Energy Storage:
  • Methanol offers a more practical storage and transportation option than hydrogen, making it a potential energy storage solution and aiding the transition to hydrogen-based energy systems.
• Versatile Feedstock:
  • Methanol is widely used in producing chemicals, solvents, and plastics, supporting various industrial applications.

What is Methanol?

• Brief: Methanol, also known as methyl alcohol or wood alcohol, is the simplest form of alcohol. It is a clear, colorless, and flammable liquid with a distinctive odor.
• Key Properties:
  • Colorless, miscible with water, toxic if ingested, flammable.

In News:

Israeli researchers from the Israel Institute of Technology have developed the PyPIM platform, which allows computers to process data directly in memory, eliminating the need for a central processing unit (CPU). This breakthrough aims to address key challenges in modern computing, particularly in terms of energy consumption and processing efficiency.

Key Features of the PyPIM Platform:

• Integration with Python and PIM Technology:
  • The PyPIM platform merges Python programming with digital processing-in-memory (PIM) technology, facilitating in-memory computing where computations occur directly within memory instead of transferring data to and from the CPU.
• Functionality and Innovations:
  • Direct In-Memory Computations: PyPIM uses specialized instructions that enable computations to take place directly in memory, reducing the need for data movement between the CPU and memory.
  • Developer-Friendly: It allows developers to use familiar languages like Python to write software for in-memory computing systems.
• Solving the "Memory Wall" Issue:
  • The platform addresses the memory wall problem, where the speed of the CPU and memory exceeds the data transfer rates, creating bottlenecks that lead to inefficiencies.
  • By performing calculations directly in memory, PyPIM reduces time and energy spent on data transfer, optimizing performance.
• Performance Improvements:
  • Energy and Time Efficiency: By minimizing energy-intensive data transfers, PyPIM leads to significant energy and time savings.
  • Simulation Tools: The platform includes tools that allow developers to simulate potential performance improvements from in-memory processing.
• Real-World Benefits:
  • Faster Processing: Tasks performed using PyPIM have demonstrated faster processing speeds, with minimal code changes, particularly in mathematical and algorithmic tasks.
  • The platform delivers a significant performance boost in areas like data analysis and algorithmic operations.

The PyPIM platform marks a pivotal advancement in computing architecture, providing a more energy-efficient and faster alternative to traditional CPU-dependent systems by reducing reliance on external memory processing and cutting down on data transfer delays.

In News:

Wave Life Sciences became the first biotechnology company to treat a genetic condition by editing RNA at the clinical level.

• What is RNA Editing?

• Definition: RNA editing is the modification of messenger RNA (mRNA) after it’s synthesized from DNA but before it is translated into proteins.
• Process: mRNA consists of exons (coding regions) and introns (non-coding regions). Exons code for proteins, while introns are removed before protein synthesis.

• Types of RNA Modifications:

• Addition: Insertion of a nucleotide.
• Deletion: Removal of a nucleotide.
• Substitution: Replacement of one nucleotide with another.

• Mechanism of RNA Editing:

• Involves Adenosine Deaminase Acting on RNA (ADAR) enzymes.
• ADAR enzymes modify adenosine to inosine, which is recognized as guanosine, allowing mRNA to be corrected.
• Guide RNA (gRNA) directs ADAR enzymes to the specific mRNA region for editing.

• Clinical Use of RNA Editing:

• Wave Life Sciences used RNA editing to treat α-1 antitrypsin deficiency (AATD), a genetic disorder.
• Other potential applications include treating diseases such as Huntington’s disease, Duchenne muscular dystrophy, Parkinson’s disease, obesity, and neurological disorders.

• Challenges in RNA Editing:

• Temporary Effects: RNA editing provides temporary changes, requiring repeated treatments for sustained effects.
• Delivery Issues: Current delivery methods, like lipid nanoparticles and adeno-associated virus vectors, have limitations in carrying large molecules.
• Specificity: ADARs may cause unintended changes in non-target regions of mRNA, leading to potential side effects.

• Comparison: RNA Editing vs. DNA Editing:

• Safety: RNA editing causes temporary changes and presents fewer risks than DNA editing, which makes permanent alterations to the genome.
• Immune Response: RNA editing uses enzymes naturally found in the body (ADAR), which reduces the risk of immune reactions, unlike DNA editing tools like CRISPR-Cas9 that can trigger immune responses.

• Significance of RNA:

• Structure: RNA is a nucleic acid, similar to DNA but typically single-stranded. It consists of a backbone of ribose sugars and phosphate groups, with bases adenine (A), uracil (U), cytosine (C), and guanine (G).
• Types of RNA:

• Messenger RNA (mRNA): Carries genetic information from DNA to ribosomes for protein synthesis.
• Ribosomal RNA (rRNA): Forms the core of the ribosome and catalyzes protein synthesis.
• Transfer RNA (tRNA): Transfers amino acids to ribosomes during protein synthesis.
• Regulatory RNAs: Regulate gene expression.

• α-1 Antitrypsin Deficiency (AATD):

• A genetic disorder where the protein α-1 antitrypsin accumulates in the liver, damaging both the liver and lungs.
• Treatments include weekly intravenous therapy or, in severe cases, liver transplants.
• RNA editing offers a potential new treatment approach.

• Global Impact:

• RNA editing is still in its early stages but shows promise for treating a wide range of genetic and chronic conditions.
• Ongoing research and clinical trials suggest RNA editing could become a key part of future gene-editing therapies.

In News:

• A new study in Geophysical Research Letters suggests that diamond dust could be more effective than any other material in reflecting solar radiation.
• Objective: The goal is to reduce global temperatures by 1.6°C by spraying approximately 5 million tonnes of diamonds annually into the atmosphere.

Background of Geoengineering Solutions:

• Geoengineering refers to large-scale interventions aimed at altering Earth's natural climate system to counteract global warming.
• One proposed solution involves spraying diamond dust in the Earth's upper atmosphere to cool the planet.
• This approach is part of Solar Radiation Management (SRM), which seeks to reflect sunlight away from Earth, thereby reducing global temperatures.
• Previous Materials Considered: Sulphur, calcium, aluminium, silicon, and other compounds have been studied to perform a similar function.

Context of Geoengineering and Climate Crisis:

• Inadequate Progress: Current efforts to mitigate global warming, such as reducing greenhouse gas emissions, have been insufficient. Global temperatures have continued to rise, and targets like the Paris Agreement's 1.5°C are increasingly out of reach.
• Rising Global Temperatures:
  • 2023: Global temperatures were approximately 1.45°C higher than pre-industrial levels.
  • Projected Challenge: To meet the Paris goal, global emissions must be reduced by at least 43% by 2030. However, current actions will likely result in only a 2% reduction by 2030.

Geoengineering Technologies:

• Geoengineering Methods:
  1. Solar Radiation Management (SRM): Reflects sunlight to cool Earth.
  2. Carbon Dioxide Removal (CDR): Involves capturing and storing CO?.
• SRM Techniques:
  • SRM draws inspiration from natural events like volcanic eruptions, where large amounts of sulphur dioxide form particles that reflect sunlight.
  • Mount Pinatubo (1991): One of the largest eruptions, which temporarily reduced global temperatures by 0.5°C due to the sulphur dioxide released.

Diamond Dust vs Other Materials:

• Study Comparison: Diamonds were found to be the most effective material compared to other compounds (sulphur, calcium, etc.) for reflecting solar radiation.
• Quantity Needed: To achieve a cooling of 1.6°C, 5 million tonnes of diamonds would need to be dispersed into the upper atmosphere each year.

Broader Geoengineering Context:

• Carbon Capture and Storage (CCS):
  • CCS is already in practice, where CO? emissions from industries are captured and stored underground to reduce atmospheric carbon.
  • However, CCS faces high costs and scalability issues, and safe storage sites for CO? are limited.
• Direct Air Capture (DAC): A more advanced method where CO? is directly removed from ambient air, but it faces even greater challenges in terms of infrastructure and cost.

In News:

Europe's Proba-3 mission to arrive in India for launch aboard PSLV-XL by ISRO

Key Highlights:

• Objective: The Proba-3 mission, led by the European Space Agency (ESA), aims to observe the Sun’s corona by creating an artificial solar eclipse. This will allow continuous observation of the Sun’s faint outer atmosphere, which is typically only visible during a natural solar eclipse.
• Key Features:
  • Artificial Solar Eclipse: The two spacecraft will fly in formation to maintain a shadow between them, enabling the uninterrupted observation of the solar corona.
  • Formation Flying: The satellites must maintain a precise formation with an accuracy of one millimetre, equivalent to the thickness of a fingernail.

Mission Details

• Launch Date: Scheduled for December 4, 2024.
• Launch Location: Satish Dhawan Space Centre near Chennai, India.
• Launch Vehicle: The PSLV-XL rocket developed by ISRO will be used for the launch.
• Spacecraft Mass: The combined mass of the two spacecraft is 550 kg.
• Orbit: The spacecraft will be placed in a highly elliptical orbit with a maximum altitude of 60,000 km to facilitate the precise formation flying.
  • This high altitude minimizes Earth’s gravitational pull and reduces the amount of propellant required to maintain their positions during the mission.

Mission Significance

• Solar Observation: The primary objective is to observe the Sun’s corona, which has been challenging to study due to its faintness. The artificial eclipse will allow continuous data collection on solar activity.
• Formation Flying: This technology will allow the two satellites to maintain autonomous flight with millimetre-level precision, which is a significant advancement in satellite formation control.
• Six-Hour Observation Windows: Each formation flying session will last for up to six hours, during which the satellites will observe the Sun's corona.

Technological and Scientific Contributions

• ASPIICS Instrument: The ASPIICS (AStronomical PIcture Camera for the Intense Corona of the Sun) will be the mission's primary instrument, developed by the Royal Observatory of Belgium. It will provide crucial data on solar activity and space weather.
• International Collaboration: The mission is a collaborative effort involving 14 ESA member states and various organizations across Europe.
• Mission Control: The mission will be managed from the ESA’s European Space Operations Centre (ESOC) in Belgium, with significant pre-launch training and preparations already underway.

ISRO's Role and Historical Context

• Launch by ISRO: The Proba-3 mission will be ISRO’s first launch for ESA since 2001, marking an important milestone in India-Europe space cooperation.
• PSLV-XL Rocket: ISRO’s PSLV-XL rocket is known for its reliability and capability in deploying satellites into precise orbits. It is well-suited to carry the 550 kg Proba-3 duo into a highly elliptical orbit for the mission.

In News:

The world's first wooden satellite, LignoSat, is set to launch from the Kennedy Space Center aboard a SpaceX rocket. This pioneering satellite is a collaborative effort between Kyoto University and Sumitomo Forestry Co., marking a significant step towards exploring more sustainable materials in space exploration.

Key Highlights:

• Purpose:The primary goal of LignoSat is to test the viability of using wood in space technology, with a focus on the eco-friendliness and cost-effectiveness of using renewable materials in satellite construction. The satellite will be tested aboard the International Space Station (ISS) to assess its durability, strength, and ability to withstand extreme space conditions.
• Material:The satellite is crafted from magnolia wood, chosen for its durability and adaptability. Magnolia was selected for its strength, making it a suitable candidate to endure the harsh conditions of space travel and the intense environmental factors faced in space exploration.
• Mission Details:Once launched, LignoSat will be sent to the ISS, where it will be released from the Japanese Experiment Module (Kibo). Researchers will collect data on the satellite’s performance, examining its ability to handle the challenges of space, including temperature fluctuations and physical strain.
• Environmental Benefits:One of the key advantages of wooden satellites is their environmental impact. Traditional metal satellites, when re-entering the Earth's atmosphere, can generate metal particles that contribute to air pollution. In contrast, wooden satellites like LignoSat are designed to be eco-friendly during reentry. Wood is a natural material that burns up more cleanly during reentry, reducing the potential for harmful atmospheric pollution.

In News:

• The Aditya-L1 mission, launched by the Indian Space Research Organisation (ISRO) on September 2, 2023, is India's first dedicated scientific mission to study the Sun.
  • Primary Payload: The Visible Emission Line Coronagraph (VELC), developed by the Indian Institute of Astrophysics (IIAp), Bengaluru, is the spacecraft's main instrument.

Key Highlights:

• First Science Outcome:The first scientific result from the mission, involving VELC, has been released. It successfully estimated the onset time of a coronal mass ejection (CME) that occurred on July 16, 2023.
  • CMEs are massive solar eruptions that can disrupt electronics in satellites and communications on Earth.
• Key Findings:
  • VELC's Role: The VELC payload was crucial in observing the CME close to the solar surface, providing a detailed understanding of its onset.
  • CMEs are typically observed in visible light after they have traveled far from the Sun. However, VELC’s unique spectroscopic observations allowed scientists to study the CME much closer to the Sun's surface.
• Publication:The results will be published in the Astrophysical Journal Letters.
• Future Significance:
  • As the Sun approaches the maximum phase of its current solar cycle (No. 25), CMEs are expected to become more frequent. Continuous monitoring with VELC will provide valuable data for understanding these events.
  • Monitoring the thermodynamic properties of CMEs near the Sun is essential to understand their source regions and behavior.
• Mission Details:
  • The spacecraft is in a halo orbit around the Lagrange Point 1 (L1), about 1.5 million kilometers from Earth.
  • Mission Lifetime: 5 years.

In News:

Centre for Science and Environment release a report on Extended Producer Responsibility (EPR) for Plastic Packaging

Key Findings:

• EPR Guidelines (2022) were a step towards enforcing the "polluter pays" principle, but the system faces significant issues in its implementation and registration processes.
• Centre for Science and Environment (CSE) report, released on October 29, 2024, highlights gaps in the EPR system for plastic packaging and suggests corrective actions.

EPR Guidelines Overview:

• Issued by: Union Ministry of Environment, Forest and Climate Change (MoEFCC).
• Objective: Hold producers, importers, brand owners (PIBOs), and plastic waste processors (PWPs) responsible for managing plastic packaging waste.
• Key Requirements:
  • PIBOs must register on a centralized portal and set targets for collection, recycling, and reuse of plastic packaging.
  • Registration involves compliance with targets on end-of-life recycling and recycled content usage.

Problems Identified in the Current EPR System:

• Low Registration and Enrollment:
  • 41,577 registrations on the EPR portal, but a significant discrepancy in the type of stakeholders registered.
  • 83% of registered entities are importers, 11% are producers, and only 6% are brand owners.
  • Producers contribute 65% of the plastic packaging in the market but have low registration.
• Absence of Key Polluters:
  • Manufacturers of virgin plastics are notably absent from the portal, despite being required to register.
• Fraudulent Practices:
  • 700,000 fake certificates were generated by plastic recyclers, far exceeding the actual certificate generation capacity.
  • The Central Pollution Control Board (CPCB) found that such fraudulent activities are undermining the integrity of the system.
  • For example, end-of-life co-processing units (e.g., cement plants) claimed to have processed 335.4 million tonnes per annum of plastic waste, while their actual capacity is just 11.4 million tonnes per annum.
• Underreporting and Mismanagement:
  • Despite 23.9 million tonnes of plastic packaging being introduced into the market, the CPCB’s estimation of plastic waste generation (4.1 MT annually) is underestimated.
• Lack of Stakeholder Representation:
  • Urban local bodies and informal waste collectors—key contributors to plastic waste management—are not included in the EPR framework, which limits their incentives and support.

Recommendations for Improvement:

• Incorporate the Informal Sector:
  • Recognize informal waste collectors and waste management agencies in the EPR framework to improve traceability and ensure better waste management.
• Eliminate Fraudulent Practices:
  • Strict actions need to be taken against fraudulent recyclers and fake certificate issuers to restore credibility to the EPR system.
• Establish Fair Pricing for EPR Certificates:
  • Undertake baseline cost studies to determine the true costs of plastic waste management, ensuring fair pricing for recycling certificates and preventing undervaluation.
• Standardize Packaging:
  • Focus on product standardization to ensure that packaging materials are uniform and easily recyclable.
• Strengthen Monitoring:
  • Improve oversight on the registration process and ensure that all polluters (producers, importers, brand owners) comply with the system’s guidelines.

EPR and Plastic Waste Management: Context and Importance

• Extended Producer Responsibility (EPR) is a policy approach where the responsibility of managing the entire lifecycle of plastic products (from production to disposal) lies with the producer.
• It is an essential part of India’s Plastic Waste Management Rules (2016), which mandate the recycling and proper disposal of plastic packaging waste.

Key Elements of EPR:

• Producer Accountability: Producers are responsible for the take-back, recycling, and final disposal of plastic packaging.
• Waste Minimization: Encourages reducing waste at the source by promoting sustainable packaging designs.
• Lifecycle Approach: Considers the entire lifecycle of the product, focusing on sustainability from production to disposal.
• Polluter Pays Principle: Ensures that the cost of waste management is borne by those responsible for generating the waste.

In News:

Scientists have discovered a "black hole triple" system, which is a rare configuration in space involving one black hole and two stars.

Overview of the Discovery:

• Location: The system is located 8,000 light years away from Earth, in the constellation Cygnus.
• Key Features:
  • A black hole at the center, currently consuming a star that is spiraling very close to it.
  • A second, more distant star that orbits the black hole every 70,000 years, and another star that orbits it every 6.5 days.

What is a Black Hole Triple System?

• Black Hole and Two Stars: Unlike typical binary systems (comprising a black hole and one other object), this system contains a black hole surrounded by two stars, one nearby and one far away.
• V404 Cygni: The central black hole in the system is the V404 Cygni, one of the oldest known black holes, roughly 9 times the mass of the Sun.

Significance of the Discovery:

• Questions on Black Hole Formation: The discovery raises new questions about how black holes are formed. Traditionally, black holes are thought to form after the explosion of a massive star (supernova), but this system does not follow that model.
• New Formation Theory: Researchers suggest the black hole may have formed via a "direct collapse" process, where a star collapses into a black hole without undergoing a supernova explosion. This is referred to as a "failed supernova".
  • In a failed supernova, the star's collapse happens too quickly for the explosive outer layers to be ejected, leading to the formation of a black hole without the typical violent explosion.

Implications for Other Binary Systems:

• The black hole’s gradual consumption of one of its stars may imply that some binary black hole systems could have originally been triple systems, with one star eventually being consumed by the black hole.

Research and Collaboration:

• Study: The discovery was made by researchers at California Institute of Technology (Caltech) and Massachusetts Institute of Technology (MIT).
• Published in: The findings were published in Nature in October 2024.

Additional Context:

• Distance: The system is about 8,000 light years away, which is vast but still observable with advanced telescopes.
• Mystery of the "Failed Supernova": The concept of a failed supernova offers new insights into the life cycle of massive stars and their transformation into black holes.

In News:

In a significant leap for the country’s space exploration aspirations, India has embarked on its first analogue space mission in Leh, a landmark step that will attempt to simulate life in an interplanetary habitat to tackle the challenges of a base station beyond Earth.

Mission Overview:

• Objective: To simulate living conditions in an interplanetary habitat, addressing challenges astronauts may face during deep-space missions (e.g., Moon, Mars).
• Goal: Study long-term isolation, habitat design, resource management, and psychological effects on astronauts.
• Partners: ISRO’s Human Spaceflight Centre, AAKA Space Studio, University of Ladakh, IIT Bombay, Ladakh Autonomous Hill Development Council.

Rationale for Ladakh:

• Geological Similarities: Ladakh’s terrain mirrors Martian and lunar surfaces, making it ideal for testing space technologies.
• Climate: Cold, dry, high-altitude conditions simulate the extreme environments of space.
• Focus Areas: Testing habitat construction, microbial studies, and survival strategies for long-duration space travel.

What are Analogue Space Missions?

• Definition: Simulated space missions on Earth designed to replicate the conditions of space exploration.
• Purpose:
  • Test technologies (e.g., life support, habitat design, in-situ resource utilization).
  • Study human behavior, psychological impacts of isolation, and operational readiness for extended space travel.
• Relevance: Crucial for preparing astronauts for missions to the Moon, Mars, or asteroids.

Significance of Analogue Missions:

• Technological Testing: Analogue missions help in evaluating systems for habitat design, life support, and health monitoring.
• Human Factors: They provide insights into crew health, teamwork under pressure, and performance during isolation.
• Psychological Studies: Address the impact of confinement, isolation, and communication delays on astronauts.
• Training: Participants (analogue astronauts) are trained for real-world space missions by conducting scientific experiments and managing emergencies.

Global Examples of Analogue Missions:

• NASA’s NEEMO: An underwater mission simulating microgravity conditions to train astronauts for space tasks.
• SIRIUS Program (UAE): Focuses on the psychological impacts of long-duration space isolation, featuring international collaborations.
• Arctic Mars Analogue Svalbard Expedition (AMASE): Uses the extreme Arctic environment of Svalbard to test Mars exploration technologies and procedures.

Relation to India’s Space Aspirations:

• Gaganyaan Mission: ISRO’s human spaceflight mission aiming to send Indian astronauts into space.
• Interplanetary Exploration: The analogue mission supports India’s broader goal of advancing human space exploration and technology development for Mars and beyond.

In News:

LiDAR (Light Detection and Ranging) is a cutting-edge remote sensing technology that uses laser pulses to measure distances and create detailed 3D maps of Earth's surface. This technology has recently played a crucial role in discovering a lost Mayan city hidden under the dense Mexican jungle.

What is LiDAR?

• Definition: LiDAR is a remote sensing technology that uses pulsed laser light to measure distances and generate precise 3D models of Earth’s surface.
• Components: The system includes a laser, a scanner, and a GPS receiver. It is usually mounted on an aircraft to map large areas of terrain.
• Data Accuracy: LiDAR can create high-resolution 3D models with vertical accuracy up to 10 cm, making it highly precise for mapping ground elevation.

How LiDAR Works

• Laser Emission: LiDAR sends out rapid laser pulses toward the ground.
• Reflection: These pulses hit the Earth’s surface, reflecting off features like vegetation, buildings, and terrain.
• Measurement: The time it takes for the laser light to travel to the ground and back is measured, allowing the system to calculate the distance between the sensor and the surface.
• Point Cloud Data: The reflected light data is collected as a "point cloud", representing all the surfaces it hits, including trees, buildings, and other features.
• Refinement: This point cloud can be processed into a Digital Elevation Model (DEM), stripping away vegetation and structures to reveal the “bare earth,” which highlights features like roads, buildings, and hidden settlements.

Why LiDAR is Useful for Archaeologists

• Large-Scale Surveying: Traditional archaeological methods often involve labor-intensive fieldwork, such as walking over every square meter and manually cutting through thick vegetation. LiDAR, however, allows researchers to quickly survey vast areas of land, even through dense jungle, from the comfort of a lab.
• Visibility Under Vegetation: LiDAR’s ability to penetrate dense foliage and reveal features beneath the surface is a game changer. Even thick tree canopies that obscure the ground are no match for the laser pulses, which can pass through gaps to illuminate hidden structures.

The Discovery of the Lost Mayan City

• The City of Valeriana: Using publicly available LiDAR data from a forest monitoring project in 2013, archaeologist Luke Auld-Thomas discovered a lost Mayan city in Mexico’s Campeche region. The city, named Valeriana, had been hidden for centuries by the thick jungle.
• City Features: The city has all the hallmarks of a Classic Maya political capital, including:
  • Multiple enclosed plazas
  • Broad causeways
  • Temple pyramids
  • A ball court
  • A reservoir formed by damming a seasonal watercourse
• Historical Significance: Valeriana is believed to date back before 150 CE and may have been a key political and cultural center in the Maya civilization.

Applications of LiDAR Beyond Archaeology

• Geography and Mapping: LiDAR is widely used to generate precise, three-dimensional data about the Earth’s surface, helping geographers and planners.
• Environmental Monitoring: It is also used in forest monitoring, flood risk assessment, and environmental conservation.
• Urban Planning and Engineering: Engineers use LiDAR for creating highly accurate topographical maps and planning infrastructure projects.

In News:

• A novel anti-counterfeiting ink has been developed using luminescent nanomaterials, which significantly enhances security in currency, certificates, medicines, and branded goods.
• The ink utilizes the luminescent properties of rare earth ions and bismuth, enabling excitation-dependent luminescence under different light sources, providing a robust solution to combat counterfeiting.

Key Features:

• Multi-Wavelength Luminescence:
  • The ink exhibits distinct colors when exposed to various wavelengths of light:
    • Vibrant blue under 365 nm UV light
    • Pink under 395 nm UV light
    • Orange-red under 980 nm near-infrared (NIR) light
  • These varying color emissions make it difficult for counterfeiters to replicate, as traditional covert tags are visible only under UV light and can be easily duplicated.

• Enhanced Durability:
  • The ink remains effective under a wide range of conditions, including varying light, temperature, and humidity, ensuring long-term usability without degradation.
• Simple Application Method:
  • The luminescent nanomaterials are synthesized through a co-precipitation method at 120°C.
  • The resulting nanomaterials are then mixed into commercially available PVC ink using sonication, allowing for easy dispersion of nanoparticles.
  • The ink is applied using screen printing to create patterns and texts that exhibit distinct color changes under different lighting conditions.
• Security Features:
  • The ink combines rare earth ions with bismuth emissions, boosting its encryption and decryption capabilities. This creates a high level of security for applications on high-value items.

Applications:

• Currency and Certificates: Enhances the authenticity of financial instruments and official documents.
• Branded Goods: Protects products from counterfeiting and fraud.
• Medicines: Helps verify the authenticity of pharmaceutical products, preventing the distribution of fake medicines.

Benefits:

• Verification: Both consumers and manufacturers can easily verify the authenticity of products, providing an accessible solution to counterfeiting.
• Practical Solution: The ink offers a practical, reliable, and non-invasive method for detecting counterfeit products, addressing a global challenge in various industries.

In News:

India's first home-grown electric propulsion satellite to be launched in Dec.

Key Highlights:

• Objective of TDS-1:

• Purpose: To demonstrate electric propulsion technology for satellite steering, using solar-powered ionized gas.
• Goal: Reduce reliance on chemical fuel, making satellites lighter and more efficient.

• Key Benefits of Electric Propulsion:

• Weight Reduction: The technology can significantly cut down satellite mass. For example, a satellite weighing 4 tonnes could be reduced to around 2 tonnes.
• Fuel Efficiency: By using electric propulsion, the need for chemical fuel is minimized, allowing for a more efficient journey to geostationary orbit.

• Technology Details:

• Fuel Used: Gases like Argon are ionized using solar power to create propulsion.
• Process: The ionized gas is expelled at high speeds to generate thrust, pushing the satellite towards its desired orbit.

• Historical Context:

• The technology was first used in GSAT-9 (South Asia Satellite) in 2017 but with imported Russian components.
• TDS-1 marks the first fully indigenous development of electric propulsion technology by ISRO, highlighting India’s increasing space autonomy.

• Significance for India’s Space Program:

• Self-Reliance: TDS-1 reflects ISRO’s growing capacity to develop advanced space technologies domestically.
• Future Prospects: This breakthrough is expected to lead to more efficient satellite designs, enhancing India’s competitiveness in the global space industry.

In News:

The Space Commission also approved a joint moon mission with Japan called the Lunar Polar Exploration Mission. For LUPEX, ISRO is developing a different moon lander than the one it used for Chandrayaan-3

New Space Missions and Developments

• Chandrayaan-4 (Moon Mission):
  • Type: Sample-return mission.
  • Launch: Expected by 2027.
  • Cost: ?2,104 crore.
  • Objective: Sample collection of moon soil and rock to return to Earth.
  • Mission Details: Two LVM-3 launch vehicles will launch components that will dock in Earth orbit before heading to the moon. The samples will be sent back using a bespoke canister.
• Lunar Polar Exploration Mission (LUPEX):
  • Collaboration: Joint mission with Japan.
  • Objective: Exploration of lunar poles with a new lander design, intended for potential crewed missions in future.
• Venus Orbiter Mission:
  • Launch Window: March 2028.
  • Cost: ?1,236 crore.
  • Objective: Study Venus' surface and atmosphere to understand planetary evolution in the Solar System.
• Next Generation Launch Vehicle (NGLV):
  • Development Budget: ?8,240 crore for first three development flights.
  • Objective: A new launcher developed with private sector collaboration for future space missions.

Cabinet Approvals for Space Initiatives

• Human Spaceflight Programme (Gaganyaan):
  • Four new missions under Gaganyaan, including an uncrewed Gaganyaan flight.
  • Focus on developing technologies for India’s first space station, Bharatiya Antariksh Station (BAS), planned by 2028.
• Space-Based Surveillance (SBS) Missions:
  • Phase 3: Approval for building 21 ISRO satellites, with 31 additional satellites by private companies.
  • Total Cost: ?26,968 crore.
• Development of a Third Launch Pad:
  • To support the NGLV and additional space missions at Sriharikota.

Upcoming Satellite Missions

• NISAR (NASA-ISRO Synthetic Aperture Radar):
  • Launch: Early 2025 on a GSAT launch vehicle.
  • Purpose: Earth observation using advanced radar technology.
  • Issue: Protective coating added due to high temperatures during testing.
• Proba-3 (European Space Agency):
  • Launch: November 29, 2024, aboard PSLV-XL.
  • Objective: Study the Sun’s corona using two satellites in formation, mimicking an eclipse to capture unique solar data.

Private Sector Involvement

• Manastu Space & Dhruva Space:
  • Collaboration: Testing green propulsion technology for the LEAP-3 mission.
  • Technology: Hydrogen-peroxide-based green propulsion system.
  • Launch: LEAP-3 mission in 2025.
• Bellatrix Aerospace:
  • Project: Prototype satellite for ultra-low earth orbit at 200 km altitude.
• Ananth Technologies:
  • Achievement: First private company to assemble, integrate, and test Space Docking Experiment (SpaDEx) satellites for ISRO.

Space Science and Research Updates

• Chandrayaan-3:
  • Findings: The crater where Chandrayaan-3 landed is older than the South Pole-Aitken Basin (4.2-4.3 billion years old).
  • Data Source: Optical High-Resolution Camera (Chandrayaan-2) and Pragyaan rover (Chandrayaan-3).
• Astrosat (India’s First Space Observatory):
  • Mission Life: Expected to last two more years (originally planned for 5 years).
  • Significance: Contributed to over 400 published papers based on multi-wavelength space observatory data.

In News:

• The Indian Space Research Organisation (ISRO) and the Department of Biotechnology (DBT) have signed an agreement to conduct biotechnology experiments on the upcoming Bharatiya Antariksh Station (BAS).
• Timeline for BAS:
  • The BAS is expected to be operational from 2028-2035, with the initial module launches slated for 2028 and full expansion by 2035.
  • It will be located at an altitude of 400 km above Earth and will support 15–20-day missions in space.

Focus Areas of Research

• Health Impact:
  • Weightlessness & Muscle Health: Studying the effects of zero-gravity on muscle loss during space missions.
  • Radiation Effects: Investigating how space radiation impacts astronaut health over long durations.
• Bio-Manufacturing:
  • Algae Studies: Exploring algae for potential use in nutrient-rich, long-lasting food sources and biofuel production.
  • Food Preservation: Identifying algae varieties that can help preserve food for longer periods in space.
• Integration with Gaganyaan Mission:
  • Experiments may also be conducted during uncrewed test flights for the Gaganyaan mission (India’s first crewed mission to space, scheduled for 2025-2026).

BioE3 (Biotechnology for Economy, Environment and Employment) Policy

• Objective: The BioE3 policy aims to boost bio-manufacturing in India, which is projected to contribute $300 billion to the Indian economy by 2030.
• Key Focus Areas:
  • High-Value Bio-Based Products: Promotes the development of bio-based chemicals, biopolymers, enzymes, and smart proteins.
  • Climate-Resilient Agriculture & Carbon Capture: Aims to strengthen agricultural practices to withstand climate change and promote carbon capture technologies.
  • Healthcare & Nutrition: Focuses on advancements in biotherapeutics, functional foods, and regenerative medicine.
  • Marine & Space Biotechnology: Encourages research in space and marine biotechnology for new applications.
  • Innovation & Entrepreneurship: Supports R&D-driven entrepreneurship through the establishment of bio-manufacturing hubs, bio-AI centers, and biofoundries.
  • Employment Growth: Aims to create skilled jobs in the growing bioeconomy, promoting green growth and sustainable industries.

Bharatiya Antariksh Station (BAS) Overview

• Structure: The station will consist of:
  • Command Module
  • Habitat Module
  • Propulsion Systems
  • Docking Ports
• Objective: To support long-term research in space life sciences and bio-manufacturing, with a focus on human health, food sustainability, and biotechnology innovations.

In News:

IndiaAI and Meta have announced the establishment of the Center for Generative AI, Srijan (????) at IIT Jodhpur, along with the launch of the “YuvAi Initiative for Skilling and Capacity Building” in collaboration with the All India Council for Technical Education (AICTE), for the advancement of open source artificial intelligence (AI) in India.

Key Initiatives Launched

• Center for Generative AI, Srijan (????) at IIT Jodhpur:
  • Focus on Generative AI (GenAI) research and innovation.
  • Meta’s support for ethical and responsible development of AI technologies.
  • Aim to empower researchers, students, and practitioners with the tools for responsible AI deployment.
  • Focus Areas: Open science, AI policy advisory, and indigenous AI application development.
• YuvAi Initiative for Skilling and Capacity Building:
  • Target: Empower 100,000 students and young developers (ages 18-30) with AI skills.
  • Core Focus: Leveraging open-source Large Language Models (LLMs) for real-world solutions.
  • Skills Development: Generative AI, open-source tools, and sector-specific AI applications (healthcare, education, agriculture, smart cities, mobility, and financial inclusion).
  • Partnership: Collaboration with AICTE (All India Council for Technical Education).

Strategic Goals and Outcomes

• Research and Innovation:
  • Strengthen India’s AI ecosystem through groundbreaking research and collaborations.
  • Focus on open-source AI and indigenous AI solutions for national challenges.
  • Empower India to lead in AI through ethical and responsible AI deployment.
• AI Talent Development:
  • Bridge the AI talent gap by training young developers in open-source AI technologies.
  • Develop AI solutions for critical sectors like healthcare, education, agriculture, smart cities, and financial inclusion.
  • Program Components:
    • GenAI Resource Hub with courses, case studies, and open datasets.
    • Unleash LLM Hackathons for students to propose AI solutions for real-world challenges.
    • Support for AI startups through an Innovation Accelerator.

Sectoral Focus and Impact

• Healthcare: AI for diagnostics, personalized medicine, and healthcare delivery.
• Education: AI tools for enhancing learning outcomes and personalized education.
• Agriculture: AI solutions for precision farming, pest control, and crop management.
• Smart Cities: AI in urban planning, traffic management, and public services.
• Mobility: AI applications in transportation, logistics, and urban mobility.
• Financial Inclusion: AI in fintech, digital payments, and financial services for underserved populations.

Additional Programs and Opportunities

• AICTE Collaboration: Mobilizing technical institutions across India to build AI capabilities.
• Master Training Activation Workshops: To introduce foundational AI concepts to students.
• Mentorship and Grants: Top AI solutions from hackathons will receive mentoring, seed grants, and market support.
• Student Startups: AI Innovation Accelerator will incubate 10 student-led AI startups experimenting with open-source models.

In News:

Precision medicine is bringing in a new era of personalised healthcare. The field began to take concrete shape when scientists were wrapping up the Human Genome Project.

Introduction to Precision Medicine:

• Precision Medicine is a novel approach to healthcare that tailors treatments and preventive strategies based on an individual’s genetics, environment, and lifestyle, instead of using a one-size-fits-all approach.
• It leverages technologies like genomics, gene editing (CRISPR), and mRNA therapeutics to address various diseases such as cancer, chronic diseases, and genetic disorders.
• Recent breakthroughs include gene therapy for restoring vision and stem cell transplants for reversing diabetes, demonstrating the transformative potential of precision medicine.

Role of Biobanks in Precision Medicine:

• Biobanks are repositories storing biological samples (blood, DNA, tissues) along with associated health data. These samples are crucial for research and development of personalized treatments.
• Large and diverse biobanks are essential for ensuring that precision medicine benefits a wide demographic, as data from homogenous groups could limit the applicability of findings.
• Recent studies using biobank data have led to breakthroughs, such as identifying rare genetic disorders and developing organoid models for high-throughput drug screening.

Precision Medicine and Biobanks in India:

• Market Growth: India’s precision medicine market is growing at a CAGR of 16%, expected to surpass USD 5 billion by 2030, contributing 36% to the national bioeconomy.
• Policy Framework: The government’s BioE3 policy aims to promote biomanufacturing, with a focus on precision therapeutics and related technologies like gene editing and cancer immunotherapy.
• Biobank Initiatives:
  • Genome India Programme: Completed sequencing of 10,000 genomes from 99 ethnic groups, aimed at identifying treatments for rare genetic diseases.
  • Phenome India Project: Focused on collecting 10,000 samples for improving prediction models for cardio-metabolic diseases.
  • Paediatric Rare Genetic Disorders (PRaGeD) Mission: Aiming to identify genes that could help develop targeted therapies for genetic diseases in children.

Regulatory and Ethical Challenges in Biobanking:

• India’s biobanking regulations are inconsistent, hindering the full potential of precision medicine. Unlike countries like the U.K., U.S., and Japan, which have comprehensive laws addressing issues like informed consent, data protection, and privacy, India lacks a cohesive regulatory framework.
• Informed Consent Issues: In India, participants provide samples without full knowledge of how their data will be used, who will have access to it, and for how long it will be stored. This lack of transparency undermines public trust in biobank research.
• Ethical Concerns: Without a clear regulatory framework, there is a risk of misuse of biological samples, such as non-consensual data sharing and sample mishandling.
• International Implications: The absence of robust laws allows foreign pharmaceutical companies to access Indian biobank data and samples without ensuring that the Indian population benefits from the resulting research or profits.

Global Comparison of Biobank Regulations:

• International Standards: Countries like the U.K., U.S., and Japan have established comprehensive biobank regulations, addressing:
  • Informed consent for sample collection and data usage.
  • Privacy protection and secure storage of genetic information.
  • Withdrawal rights for participants at any stage of research.
• India’s biobank regulations lack clear provisions for data protection and participant rights, limiting the effectiveness of research and undermining public confidence in biobanks.

In News:

• Scientists have developed an ultrasound-based technique for detecting cancer, aiming to replace traditional biopsies, which are invasive and painful.
• Promising Alternative: The method uses high-energy ultrasound to release biomarkers (RNA, DNA, and proteins) from cancerous tissue into the bloodstream, allowing for early cancer detection with minimal discomfort.
• Presented at Acoustical Society Conference: The technique was discussed at the joint meeting of the Acoustical Society of America and Canadian Acoustical Association in May 2024.

Traditional Cancer Detection vs. New Ultrasound Approach

• Current Gold Standard - Biopsy: Traditionally, cancer is diagnosed using biopsies, where a tissue sample is extracted using a needle from suspected cancerous areas. Although effective, biopsies are invasive, painful, and carry some risks.
• Ultrasound as a Non-Invasive Alternative: The new method involves using high-frequency ultrasound waves to break off cancerous tissue into droplets, which are then released into the bloodstream. The biomarkers in the droplets can be analyzed for cancerous mutations.
• Enhanced Sensitivity: This ultrasound-based technique increases the levels of genetic and vesicle biomarkers in blood samples by over 100 times, enabling the detection of cancers and specific mutations that are otherwise undetectable in blood.

Key Findings of the Research

• Single Cancer Cell Detection: The technique allows for the detection of a single cancer cell in blood samples. It works by passing ultrasound waves through isolated blood samples, which break apart circulating cancer cells, releasing biomarkers into the blood.
• Cost-Effective: Traditional methods for detecting circulating cancer cells are costly (e.g., the ‘CellSearch’ test costs $10,000). In contrast, this ultrasound method can detect cancer with a much lower cost, around $100 (?8,400).
• Potential for Early Diagnosis: The research shows promise for detecting cancer at an early stage, even before symptoms appear, using blood samples.

Challenges and Next Steps

• Need for Large-Scale Clinical Trials: While the technique shows potential, large cohort studies involving diverse patient groups across different geographies and ethnicities are needed to validate the approach.
• Long-Term Study for Effectiveness: Further research is required to ensure the accuracy and reliability of the technique across various cancer types and to determine the ideal biomarker thresholds for early detection.
• Regulatory Approval and Commercialization: If the clinical trials yield positive results, the method could be commercially available in approximately five years, following regulatory approval.

Understanding Cancer and Its Types

• Cancer Definition: Cancer refers to the uncontrolled growth of abnormal cells that can form tumors and spread to other parts of the body.
• Types of Cancer:
  • Carcinoma: Cancer originating in epithelial cells (e.g., breast, lung, prostate cancer).
  • Sarcoma: Affects connective tissues like bones and muscles.
  • Leukemia: Affects blood-forming tissues, leading to abnormal white blood cell production.
  • Lymphoma: Begins in immune cells, including Hodgkin and non-Hodgkin lymphoma.
  • Melanoma: Cancer of pigment-producing skin cells.
• Key Differences Between Normal and Cancer Cells:
  • Cancer cells grow uncontrollably and evade immune detection.
  • Cancerous cells accumulate chromosomal abnormalities, unlike normal cells, which follow regulated growth patterns.

In News:

• The National Education Society for Tribal Students (NESTS) launched the third phase of the Amazon Future Engineer Program in 50 Eklavya Model Residential Schools (EMRS).
• Schools involved are spread across Andhra Pradesh, Gujarat, Karnataka, Madhya Pradesh, Odisha, Telangana, and Tripura.

Program Focus Areas:

• Emerging Technologies: The third phase introduces tribal students to key areas like:
  • Blockchain technology
  • Artificial Intelligence (AI)
  • Coding and block programming
• The program is designed to equip students with skills in computer science fundamentals.

Teacher Training:

• A four-day in-person training workshop for teachers was conducted to empower them with the skills necessary to teach emerging technologies effectively.
• Teachers also participated in the EMRS Coders Expo, showcasing top student coding projects from the previous academic year.

Target Audience:

• Students: The program targets students from grades 6 to 9. Class 10 students will participate in project-based virtual sessions aligned with the CBSE AI Skills Curriculum.
• The goal is to enhance students' understanding of computer science and technology and prepare them for STEM (Science, Technology, Engineering, Mathematics) careers.

Program Expansion:

• Future Plans: The program will be rolled out in the next phase to cover a total of 410 EMRSs across India.
• Impact: Over 7,000 students in grades 6 to 8 have already benefited from the program’s introduction to computer science and block programming.

Key Goals of the Program:

• Empower Tribal Students: Provide tribal students with modern technological skills to prepare them for future STEM careers.
• Capacity Building: Equip both teachers and students with the knowledge and skills to engage with emerging technologies.
• Fostering Technological Literacy: The initiative aims to foster technological literacy and modernize education in tribal areas.

Recognition:

• During the event, Top 3 Student Coding Projects were felicitated for their creativity and innovation.
• The Top 3 IT Teachers were also recognized for their dedication in guiding students through the program.

Partnership with Amazon:

• The program is a collaboration between NESTS and Amazon, showcasing a joint effort to improve educational access and technological skill development among tribal students.

In News:

The tiny nematode Caenorhabditis elegans (C. elegans) has played an outsized role in scientific discovery, contributing to four Nobel Prizes over the years.

Key Discoveries from C. elegans Research

• C. elegans and Cellular Processes:
  • The worm has helped scientists understand programmed cell death (apoptosis), a vital process in development and disease. This work contributed to the 2002 Nobel Prize in Physiology or Medicine, addressing how cells are instructed to kill themselves and how this process goes awry in conditions like AIDS, strokes, and degenerative diseases.
• Gene Silencing and RNA Interference:
  • In 2006, a Nobel Prize was awarded for the discovery of gene silencing via RNA interference (RNAi), a process first explored using C. elegans. This discovery led to the development of a new class of RNA-based drugs.
• Cellular Imaging Techniques:
  • In 2008, C. elegans contributed to breakthroughs in cellular imaging, as its use helped invent cellular “lanterns” that allowed scientists to visualize the inner workings of cells, earning a Chemistry Nobel.
• Gary Ruvkun’s 2024 Nobel:
  • Gary Ruvkun’s Nobel Prize in Physiology or Medicine in 2024 was the fourth in a series of Nobel recognitions stemming from C. elegans research, reinforcing its role in fundamental biological discoveries.

Key Facts About Caenorhabditis elegans (C. elegans):

• Size: 1 millimeter long.
• Life Cycle: Completes in 3-5 days.
• Cell Count: 959 cells.
• Genome: First multicellular organism to have its full genome sequenced in 1998.
• Sexual Reproduction: Hermaphroditic (self-fertilizing) and male.
• Scientific Role: Used to study genetics, developmental biology, neuroscience, and cell biology.
• Nobel Prize Contributions: Four Nobel Prizes, including those in Physiology, Medicine, and Chemistry, for advancements in cell death, gene silencing, and imaging.

Why is it in the News?

For the first time, astronomers have observed the area right at the edge of a black hole where matter stops orbiting and plunges straight in at near-light speed.

What is the Plunging Region of a Black Hole?

• The plunging region of a black hole is an area where matter ceases to orbit the celestial object and instead falls directly into its incalculable depths.
  • This phenomenon was initially predicted by Albert Einstein's groundbreaking theory of general relativity, which continues to shape our understanding of the cosmos.
• As matter approaches a black hole, it is torn apart and forms a rotating ring known as an accretion disc.
• According to general relativity, there exists an inner boundary within this disc, beyond which nothing can maintain its orbit around the black hole.
  • Instead, the material is drawn towards the black hole at nearly the speed of light, marking the beginning of the plunging region.
• This region, situated just outside the event horizon, represents the point of no return for matter falling into a black hole.
• Despite the challenges posed by studying these enigmatic structures, researchers believe that investigating plunging regions could unveil new insights into the formation and evolution of black holes.
• Additionally, these studies may offer valuable information about the fundamental properties of space-time, potentially transforming our understanding of the universe and its most mysterious inhabitants.

What is a Black Hole?

• A black hole is a celestial phenomenon that arises from the remnants of a massive star that has exhausted its nuclear fuel and undergone gravitational collapse.
• It is characterized by an unfathomably dense core, known as a singularity, which is enveloped by a boundary called the event horizon.
• The event horizon serves as a point of no return; any matter or light that crosses this boundary is irrevocably drawn towards the singularity, making it impossible to escape the immense gravitational pull.

Black holes are classified into three categories based on their size and formation process:

• Stellar-mass black holes: These form when a massive star collapses at the end of its life cycle. They typically have masses ranging from approximately five to several dozen times that of our Sun.
• Supermassive black holes: Found at the centre of most galaxies, including our own Milky Way, these colossal structures boast masses that can reach billions of times the mass of the Sun.
• Intermediate-mass black holes: With masses between those of stellar mass and supermassive black holes, these entities are thought to form through the merger of smaller black holes or the collapse of dense clusters of stars.
• Due to their extreme nature, black holes have been the subject of extensive research and fascination in the scientific community.
• The study of these enigmatic structures continues to yield invaluable insights into the fundamental principles governing our universe.

Why is it in the News?

The Indian Science Congress, the largest gathering of scientists and students of science in the country and a permanent annual fixture in the calendar of the participant group for more than a century has been postponed.

Postponement of the Indian Science Congress:

• Unprecedented Interruption: The postponement of the Indian Science Congress holds unprecedented significance.
  • Since its inception in 1914, the Congress has been an annual event, except for the years immediately following the onset of the Covid-19 pandemic (2021 and 2022).
• Tradition and Prime Ministerial Engagement: A cornerstone of scientific tradition, the Indian Science Congress is inaugurated by the Prime Minister, making it a fixture on the PM's calendar.
  • Typically, it stands as the Prime Minister's first public engagement of the new year.

Why has the Science Congress Been Postponed This Year?

• This year's postponement stems from a protracted dispute between the Indian Science Congress Association (ISCA), the organizing body, and the Department of Science and Technology (DST) within the Union Ministry of Science and Technology.
• The DST, a key funding entity, withdrew support in September 2023, citing financial irregularities.
• The ISCA refuted the allegations and contested the DST's directive prohibiting government funds for Science Congress-related expenses, leading to an impasse that has resulted in the postponement.
• A legal challenge to the DST's decision is currently pending.

What is the Indian Science Congress (ISC)?

• The Indian Science Congress (ISC) is a unique event in the country that serves as a platform for scientific communities to interact with students and the general public on science-related matters.
• Organized by the Indian Science Congress Association (ISCA), an independent body supported by the Department of Science and Technology (DST) in the central government, the Science Congress is an annual five-day event from January 3 to 7, considered a permanent fixture on the Prime Minister’s calendar.
• The inaugural session of the Indian Science Congress took place in 1914 at the premises of the Asiatic Society, Calcutta.
• In recent years, the Indian Science Congress (ISC) has faced criticism due to issues such as a lack of substantial discussions, the promotion of pseudoscience, and outlandish claims by certain speakers.
  • This has led to concerns among prominent scientists, with some advocating for the discontinuation of the event or, at the very least, the withdrawal of government support.
  • While the government provides an annual grant for organizing the Science Congress, it does not play a direct role in its organization.

Why is it in the News?

The study by ICAR-Indian Veterinary Research Institute (ICAR-IVRI), Izatnagar, Bareilly has found the exact status of EEHV and its subtypes circulating among the Asian elephant population in India.

What is Elephant Endotheliotropic Herpesvirus (EEHV)?

• Elephant endotheliotropic herpesvirus (EEHV) is responsible for one of the most devastating viral infectious diseases in elephants worldwide, especially young Asian elephants.
• EEHV is a double-stranded DNA virus that is classified in the family Herpesviridae.
• The mortality rate is very high (70-85%) and death occurs within a short period (2-4 days).
• In India, the incidence of EEHV-HD was first reported in 1997.
• 9 of 15 potential cases were confirmed from Southern India in wild free-ranging calves in Kerala, Karnataka, Tamil Nadu forest reserves, and Madras Zoo.
• Transmission of the disease: EEHV is mostly spread through mucosal secretions which include:
• Saliva, Breast milk, Nasal secretions, Trunk to trunk contacts etc
• The disease can only affect elephants and is not infectious to humans or other animals.
• Symptoms: Some elephants show symptoms such as reduced appetite, nasal discharge and swollen glands.
• Treatment: Treatment involves a combination of strategies such as antiviral therapy, aggressive fluid therapy to counter haemorrhaging, immuno-stimulant drugs like selenium and Vitamins C and E, as well as antipyretics and analgesics to manage fever.
• It's important to note that there is no definitive cure for herpesviruses in animals or humans since these viruses typically enter a latent state.

Why in the News?

The 9th edition of the India International Science Festival (IISF) 2023 will be held at Faridabad, Haryana from January 17th-20th, 2024.

About the India International Science Festival (IISF):

• The India International Science Festival (IISF) is an annual science festival organized by the Ministry of Science and Technology, the Ministry of Earth Science, and Vijnana Bharati in India.
• The festival aims to promote science and technology in India and to showcase the latest advancements in these fields.
• The IISF has been held every year since 2007.
• The festival typically lasts for four days and features a variety of events, including exhibitions, seminars, workshops, and competitions.
• The exhibitions feature displays of scientific and technological innovations from India and around the world.
• The seminars and workshops provide opportunities for scientists and technologists to share their knowledge with the public.
• The competitions encourage students to participate in science and technology.
• The IISF is a major event in the Indian scientific community and has been praised for its role in promoting science education and public awareness of science.
• The festival has also been successful in attracting international participation, with scientists and technologists from around the world attending the event.
• The 2022 IISF was held in Bhopal, Madhya Pradesh, from January 21 to 24.

India International Science Festival (IISF) 2023:

• It will be held at the Campus of Translational Health Science and Technology Institute (THSTI) and Regional Centre for Biotechnology (RCB) of the Department of Biotechnology in Faridabad.
• Theme: 'Science and Technology Public Outreach in Amrit Kaal'.
• IISF 2023 will have a total of 17 themes to showcase scientific achievements, offering diverse benefits to participants and the general public.

Why in the News?

The Euclid mission, which will investigate the mysteries of dark matter and dark energy, released its first five science images recently.

About Euclid Mission:

• Euclid is a European mission, built and operated by European Space Agency (ESA), with contributions from NASA.
• Euclid is designed to give important new insights into the "dark side" of the universe -- namely dark matter and dark energy, both thought to be key components of our cosmos.
• It was launched from Cape Canaveral, Florida, (USA) on 1 July 2023 and the launch vehicle used was ‘SpaceX Falcon 9’.
• The mission derives its name from Euclid of Alexandria, an ancient Greek mathematician from around 300 BC, who laid the foundations of geometry.
• Euclid Mission Objective: The primary goal of the Euclid mission is to create a three-dimensional map of the universe, with time as the third dimension.
• This will be achieved by observing billions of galaxies, extending up to 10 billion light-years away, and covering over a third of the celestial sphere.
• Euclid will explore how the Universe has expanded and how structure has formed over cosmic history, revealing more about the role of gravity and the nature of dark energy and dark matter.
• The Euclid Consortium – consisting of more than 2,000 scientists from 300 institutes in 13 European countries, the U.S., Canada, and Japan – is responsible for providing the scientific instruments and scientific data analysis.
• NASA provided the detectors of the Near-Infrared Spectrometer and Photometer, NISP.
• Euclid is a medium-class mission in ESA’s Cosmic Vision Programme.