In News:

JNU scientists make big discovery that could change malaria, Covid-19 treatment.

Overview of the Discovery:

• Institution: Jawaharlal Nehru University (JNU), Special Centre for Molecular Medicine.
• Key Discovery: Identification of human protein Hsp70 as a critical factor in the spread of malaria and COVID-19.
• Research Collaboration: Involvement of Indian and Russian researchers.
• Outcome: Development of a small molecule inhibitor of Hsp70 that could act as a broad-spectrum treatment for multiple infections.

About Heat Shock Protein 70 (Hsp70):

• Definition: Hsp70 is a type of molecular chaperone protein.
• Function:
  • Helps other proteins fold into their proper shapes.
  • Prevents protein misfolding.
  • Regulates protein synthesis and protects proteins from stress.
  • Elevates during cellular stress to shield cells from damage.
• Role in Cellular Processes:
  • Prevents protein aggregation and assists in protein transport across membranes.
  • Plays a critical role in protein homeostasis and cell survival during stress conditions.

Hsp70's Role in Disease Spread:

• SARS-CoV-2 (COVID-19) Interaction:
  • Hsp70 interacts with the spike protein of SARS-CoV-2 and human ACE2 receptors.
  • Facilitates viral entry into human cells by stabilizing this interaction during fever (when Hsp70 levels rise).
• Malaria:Pathogens like malaria parasites rely on the host's machinery for survival, including Hsp70.

Research Findings and Implications:

• Published in: International Journal for Biological Macromolecules.
• Inhibition of Hsp70:
  • Targeting Hsp70 can disrupt viral replication.
  • In lab tests, Hsp70 inhibitor (PES-Cl) blocked SARS-CoV-2 replication at low doses.
• Potential for Broad-Spectrum Treatment:
  • Hsp70 could be a target for treating multiple infections, not limited to COVID-19 or malaria.
• Prevention of Drug Resistance:
  • Host-targeting antivirals are less prone to resistance as the virus cannot mutate the host protein (Hsp70).
  • This approach could be especially beneficial for combating rapidly evolving viruses like SARS-CoV-2 and its variants (e.g., Omicron).

Host-Targeting Approach vs. Traditional Drugs:

• Host-Targeting: Targets the host cell machinery (e.g., Hsp70) rather than the virus itself.
  • Reduces the likelihood of viral mutation-induced resistance.
• Traditional Drugs: Target the virus directly, which can lead to resistance, especially with rapidly mutating viruses.

Global Health and Pandemic Preparedness:

• Universal Tool for Infectious Diseases: The discovery could serve as a universal tool for managing infections during health emergencies.
• Collaboration and Importance: Highlights the significance of international collaboration in addressing global health challenges (e.g., Dr. Pramod Garg of AIIMS, Ph.D. scholar Prerna Joshi).
• Future Implications:Preparation for future pandemics, as the world must remain vigilant even post-COVID-19.