In News:

As Delhi’s AQI worsened, the Commission for Air Quality Management issued the order to activate Stage-IV of the Graded Response Action Plan.

Restrictions Under GRAP-IV in Delhi-NCR

• Truck Movement:
  • Banned except for essential goods and trucks using clean fuels (LNG, CNG, BS-VI diesel, or electric).
  • Non-essential light commercial vehicles registered outside Delhi are also banned unless they are CNG or BS-VI diesel or electric vehicles (EVs).
  • Delhi-registered BS-IV or older diesel vehicles (medium and heavy goods vehicles) are banned, except for those in essential services.
• Construction Activities:Suspension of all construction work, including public projects like highways, roads, flyovers, power lines, pipelines, etc.
• Schools and Work:
  • Online classes for students of Classes 6 to 9 and Class 11.
  • Work from home (WFH) recommendations for 50% office capacity in NCR.
  • Central government employees may also be asked to work from home.
  • Offline classes for Classes 10 and 12 continue, but schools for other classes must shift to online mode.
• Other Measures:
  • State governments may impose additional measures such as:
    • Closure of colleges.
    • Odd-even vehicle scheme.
    • Restrictions on non-essential commercial activities.

About GRAP (Graded Response Action Plan)

• Purpose: A plan to reduce air pollution in the Delhi-NCR region based on AQI levels.
• Approved By: Supreme Court in 2016 (M.C. Mehta v. Union of India).
• Notified by MoEFCC: 2017.
• Implementation Authority: CAQM (Commission for Air Quality Management).

Stages of GRAP

GRAP is an incremental system, with measures activated as air quality deteriorates:

• Stage 1: Poor AQI (201-300) – Basic pollution control measures.
• Stage 2: Very Poor AQI (301-400) – Enhanced measures.
• Stage 3: Severe AQI (401-450) – Stricter actions like shutting down industries.
• Stage 4: Severe Plus AQI (Above 450) – Most stringent restrictions, as activated on November 18, 2024.

Air Quality Index (AQI)

• Introduced: 2014, by Central Pollution Control Board (CPCB).
• Categories:
  • Good: 0-50
  • Satisfactory: 51-100
  • Moderately Polluted: 101-200
  • Poor: 201-300
  • Very Poor: 301-400
  • Severe: 401-450
  • Severe Plus: 451 and above (current status in Delhi).
• Pollutants Considered: PM10, PM2.5, NO?, SO?, CO, O?, NH?, and Pb.
• Measurement: 24-hour average values for PMs, and 8-hour averages for CO and O?.

Commission for Air Quality Management (CAQM)

• Established: Under the Commission for Air Quality Management in National Capital Region (NCR) Act, 2021.
• Mandate: To coordinate, research, and manage air quality issues in the NCR and adjoining areas.
• Composition: Includes government officials, technical experts, and NGO representatives.
• Jurisdiction: Covers Delhi and parts of Haryana, Uttar Pradesh, and Rajasthan.

In News:

• World Diabetes Day is observed on November 14th each year to raise awareness about diabetes, its prevention, and management.
• It was created by the International Diabetes Federation (IDF) and the World Health Organization (WHO).

• Significance: Commemorates the birthday of Sir Frederick Banting, who co-discovered insulin in 1922 alongside Charles Best.
• Theme (2024): "Access to Diabetes Care: Empowering Better Health for All".

History:

• Established in 1991 by the International Diabetes Federation (IDF) and World Health Organization (WHO).
• Recognized as a global observance by the UN in 2006.
• Activities: Awareness campaigns, health check-ups, educational seminars, and lighting of Blue Circle Monuments worldwide as a symbol of unity in the fight against diabetes.

Global Diabetes Data (2022):

• Total Diabetic Adults: 828 million globally.
• India's Share: 212 million (approximately 25% of global cases).
• Other Countries:

• • China: 148 million.
  • USA: 42 million.
  • Pakistan: 36 million.
  • Indonesia: 25 million.
  • Brazil: 22 million.

Risk Factors for Diabetes:

• Global Factors: Obesity and poor diets are key contributors.
• India-Specific Factors: Dietary habits, lack of exercise, and socio-economic disparities contribute significantly to the high prevalence.

Untreated Cases:

• Global untreated cases (2022): 445 million (59% of diabetics globally).
• India untreated cases (2022): 133 million (64 million men, 69 million women).
• Complications: Untreated diabetes leads to severe health complications, including heart disease, kidney failure, and premature death.

Types of Diabetes:

• Diabetes Mellitus: The most common type of diabetes, characterized by issues with insulin production or its efficient use.
  • Type 1 Diabetes (T1D):
    • Autoimmune condition where the pancreas produces little or no insulin.
    • Primarily affects children and young adults.
  • Type 2 Diabetes (T2D):
    • Insulin resistance combined with reduced insulin production.
    • Often linked to lifestyle factors like obesity and physical inactivity.
  • Gestational Diabetes:
    • Occurs in pregnant women, leading to high blood sugar.
    • Typically resolves after childbirth.
  • Diabetes Insipidus:
    • Imbalance of water regulation due to inadequate secretion or response to antidiuretic hormone (ADH).
    • Leads to excessive urination and dehydration.

Symptoms of Diabetes:

• Frequent urination.
• Excessive thirst and hunger.
• Unexplained weight loss.
• Blurred vision.
• Fatigue.
• Slow-healing wounds.

Role of Insulin in Managing Diabetes:

• Function of Insulin: A hormone produced by the pancreas that helps regulate blood glucose levels by facilitating glucose uptake into cells.
• In Type 1 Diabetes: Insulin injections or pumps are essential for survival.
• In Type 2 Diabetes: Insulin or oral medications may be prescribed alongside lifestyle modifications like diet and exercise.

Government Initiatives in India:

• National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular Diseases, and Stroke (NPCDCS): Focuses on awareness, early diagnosis, and management of diabetes.
• National Health Policy (2017): Aims to reduce premature deaths from non-communicable diseases by 25% by 2025.
• Ayushman Bharat – Health and Wellness Centres: Provides free screenings and consultations for diabetes and other non-communicable diseases.
• Eat Right Movement: Promotes healthier dietary habits to combat obesity and reduce diabetes risks.
• School Health Programs: Aims to educate children on healthy lifestyles to prevent the early onset of Type 2 diabetes.

In News:

• Defence Minister Shri Rajnath Singh introduced the concept of ‘Adaptive Defence’ at the inaugural Delhi Defence Dialogue (DDD).
• Adaptive Defence aims to prepare India's military for the rapidly changing landscape of modern warfare, with evolving threats and technologies shaping global security.

Key Aspects of Adaptive Defence:

• Strategic Approach:
  • Adaptive Defence is an evolving strategy where military and defence systems continuously adjust to emerging threats, focusing on proactive preparedness rather than reactive responses.
  • It is based on anticipating future threats, fostering flexibility, resilience, and agility in both strategic and tactical responses.
• Core Elements:
  • Situational Awareness: The ability to understand and respond to dynamic, often unpredictable environments.
  • Flexibility & Agility: At both the strategic and tactical levels to ensure swift and effective responses.
  • Resilience: The capacity to recover and adapt quickly to unforeseen circumstances.
  • Integration with Emerging Technologies: Emphasis on adopting cutting-edge technologies like AI, drones, and cybersecurity to stay ahead of adversaries.

The Changing Nature of Warfare:

• Grey Zone & Hybrid Warfare:
  • Modern conflicts now often occur in the grey zone and involve hybrid warfare, blending traditional and non-traditional threats like cyber-attacks, terrorism, and psychological warfare.
  • These new threats demand continuous adaptation in strategies, doctrines, and military operations.
• Technological Transformation:
  • Drones and swarm technologies are reshaping warfare. India aspires to become a global hub for drones, leveraging these technologies for both economic and military growth.
  • The increasing significance of Artificial Intelligence (AI), cyber capabilities, and quantum technologies in defence highlights the need for international collaboration in research and innovation.
• Psychological Warfare:
  • The rise of information overload and psychological warfare challenges traditional defence paradigms. Manipulation of information to influence public opinion and disrupt decision-making processes is now a key threat.

Government Initiatives for Adaptive Defence:

• Institutional Strengthening:
  • Establishment of the Chief of Defence Staff (CDS) and initiatives to enhance jointness among the three armed services (Army, Navy, Air Force) to create a unified strategic force.
  • Reform of training curricula and emphasis on integrated operations to ensure readiness for new-age warfare.
• Focus on Self-Reliance:
  • Strengthening the indigenous defence sector through initiatives like Make in India and the Aatmanirbhar Bharat campaign.
  • Increasing foreign direct investment (FDI) in defence and promoting defence exports, with India currently exporting to over 100 nations.
• Drone Hub Vision:
  • India aims to become the world’s drone hub, supporting R&D and fostering innovation to develop reliable certification mechanisms and enhance Indian intellectual property in the drone sector.
  • Programs like iDEX (Innovations for Defence Excellence) and ADITI are rewarding innovation and driving India's defence sector towards greater self-sufficiency.
• Technology and Innovation:
  • Focus on cybersecurity, AI, and quantum technologies to develop solutions that address both national and global security challenges.
  • India is also working on Theaterisation, integrating the three services into a unified force structure for enhanced coordination and joint operations.
• Defence Acquisition and Export:
  • Introduction of the Defence Acquisition Procedure 2020, establishment of Defence Industrial Corridors in Uttar Pradesh and Tamil Nadu, and a Positive Indigenisation List to boost self-reliance.
  • India is actively increasing defence exports, aiming for Rs 50,000 crore worth of exports by 2029, with key export destinations including the USA, France, and Armenia.

Strategic Vision for the Future:

• Collaborative Approach:
  • Given the interconnectedness of global security, the defence minister emphasized the importance of a collaborative approach in dealing with transnational threats.
  • Cross-border issues, cyberspace threats, and the potential of quantum and nanotechnologies demand the sharing of knowledge and strategies across borders.
• Joint Military Vision:
  • Jointness in defence strategy should go beyond national borders and should involve international cooperation in response to global security challenges.
  • The need for interconnected solutions in the face of transnational threats underscores the importance of multilateral cooperation.

In News:

• Cambodia saw a resurgence of H5N1 avian influenza cases after over 10 years of no human infections.
• From February 2023 to August 2024, 16 human cases were reported, with 3 deaths caused by the A/H5 clade 2.3.2.1c virus.
• Notably, 14 of these cases were caused by a novel reassortant virus, involving a mixture of clade 2.3.2.1c and clade 2.3.4.4b gene segments.

Key Points:

• Reassortment of the Virus:
  • The reassortment between clades 2.3.2.1c (Southeast Asia) and 2.3.4.4b (global spread) has created a new strain.
  • This reassortant virus is responsible for the second wave of infections in humans, starting in October 2023.
• Zoonotic Transmission:
  • Investigations confirmed that direct contact with sick poultry or bird droppings was the primary source of human infections.
  • There have been no reported cases of human-to-human transmission.
  • The novel reassortant virus appears to have replaced the 2.3.2.1c strain in Cambodian poultry.
• Geographic Spread and Spillovers:
  • Clade 2.3.2.1c was first reported in Cambodian poultry in March 2014. It continued to circulate in both poultry and wild birds.
  • Clade 2.3.4.4b viruses began circulating in Cambodian live bird markets by 2021, co-existing with clade 2.3.2.1c.
  • There were two key spillovers to humans:
    • The first spillover in February 2023, associated with clade 2.3.2.1c, involved two related individuals, with one death.
    • The second spillover, beginning in October 2023, involved the novel reassortant virus.
• Genetic Analysis and Mutation Concerns:
  • Genetic sequencing showed significant changes in the hemagglutinin (HA) gene of viruses from human cases, indicating a shift from older local strains to newer sublineages.
  • The PB2 627K mutation in the novel reassortant is concerning, as it is linked to increased mammalian adaptation and the potential for airborne transmission, particularly in mammals like ferrets.
  • This mutation raises concerns about the virus’s ability to adapt to humans or other mammals.
• Environmental and Epidemiological Factors:
  • The reassortment is believed to have been facilitated by:
    • High-density poultry farming.
    • Wild bird migration.
    • Cross-border poultry trade in Southeast Asia.
  • These factors heighten the risk of zoonotic transmission, emphasizing the need for continued vigilance in the region.
• Surveillance and Response:
  • One Health investigations linked human cases to infected poultry, highlighting the importance of rapid response through whole genome sequencing.
  • The ongoing surveillance is critical, as the novel reassortant strain has already replaced clade 2.3.2.1c in Cambodian poultry.
• Public Health Recommendations:
  • There is an urgent need to strengthen sustained surveillance of avian influenza in both poultry and wild birds, particularly in Southeast Asia.
  • Public health strategies should focus on:
    • Reducing human exposure to infected poultry.
    • Promoting safe poultry handling practices.
    • Encouraging early healthcare-seeking behavior in individuals with potential symptoms.

In News:

ICMR announces ‘First in the World Challenge’ to encourage scientists to find innovative ideas to tackle health issues.

Key Highlights:

• Objective:
  • Encourage bold, out-of-the-box ideas for solving difficult health problems.
  • Aim to foster novel and groundbreaking biomedical innovations (vaccines, drugs, diagnostics, interventions, etc.).
  • Target projects that are “first of their kind” and have never been tried or tested globally.
• Key Features of the Initiative:
  • Focus on Groundbreaking Innovations:
    • Emphasis on high-risk, high-reward ideas with potential for significant global health impact.
    • Excludes proposals aiming for incremental knowledge or process innovation.
  • Scope of Research:
    • Breakthroughs in biomedical and health technologies such as:
      • Vaccines
      • Drugs/Therapeutics
      • Diagnostics
      • Interventions
• Funding & Support:
  • Provides funding for projects at various stages, from proof-of-concept to prototype development and final product.
  • Support for projects that have the potential to lead to “first-of-its-kind” biomedical innovations.
• Application Process:
  • Open to individual researchers or teams (from single or multiple institutions).
  • Teams must designate a Principal Investigator responsible for the project’s technical, administrative, and financial aspects.
• Selection Criteria:
  • A selection committee will be formed with:
    • Experts, innovators, policymakers, and distinguished scientists with an outstanding research record.
    • Proposals evaluated based on originality, impact potential, and innovation.

About the Indian Council of Medical Research (ICMR)

• History:Founded in 1911 as the Indian Research Fund Association (IRFA), renamed ICMR in 1949.
• Role & Mandate:
  • Ministry of Health and Family Welfare, Government of India.
  • Formulates, coordinates, and promotes biomedical research in India.
  • Focus on improving public health and addressing national health challenges.
• Vision:“Translating Research into Action for Improving the Health of the Population.”

In News:

The 2024 edition of The Lancet Countdown on Health and Climate Change presents critical insights into the intersection of health and climate change.

Key Findings from the 2024 Report

• Air Pollution and Mortality in India:
  • In 2021, air pollution was responsible for 1.6 million deaths in India.
  • Fossil fuels (coal and liquid gas) were identified as major contributors, accounting for 38% of these deaths.
  • India was ranked as the second-highest emitter of PM2.5 globally in 2022, contributing 15.8% of consumption-based and 16.9% of production-based PM2.5 emissions.
• Impact of Heat Stress:
  • In 2023, India experienced 2400 hours (or 100 days) of moderate to high heat stress, particularly during light outdoor activities like walking.
  • Heatwaves have become more frequent, with adults over 65 years experiencing 8.4 heatwave days per year, a 58% increase from 1990-1999.
  • This increased heat exposure has led to a loss of 181 billion labor hours globally, translating into an economic loss of approximately $141 billion.
• Global and National Trends in Air Pollution:
  • PM2.5 is particularly hazardous because it is fine enough to enter the lungs and bloodstream, leading to severe health risks like respiratory and cardiovascular diseases.
  • Nitrogen Dioxide (NO?), Sulphur Dioxide (SO?), Carbon Monoxide (CO), and Ozone (O?) were identified as other pollutants contributing to poor air quality in India.
• Health Impact of Extreme Weather:
  • The 2023 heatwave was one of the hottest years on record, exacerbating health risks worldwide, especially for the elderly.
  • Droughts and heatwaves also contributed to a rise in food insecurity, affecting millions globally.
• Disease Transmission and Climate Change:
  • Dengue transmission potential rose by 85% from 1951-1960 to 2014-2023.
  • Coastal areas suitable for the spread of Vibrio pathogens, which cause cholera, expanded by 23%, affecting over 210 million people.
• Health Effects of Fossil Fuel Pollution:
  • Continued reliance on fossil fuels worsens air quality, leading to health problems such as respiratory diseases, cardiovascular issues, and adverse pregnancy outcomes.

Government Efforts to Tackle Air Pollution in India

• National Clean Air Programme (NCAP):
  • NCAP is a national strategy to reduce air pollution across India, with specific action plans for 131 non-attainment cities. The initiative is supported through various central government schemes such as:
    1. Swachh Bharat Mission (Urban)
    2. Atal Mission for Rejuvenation and Urban Transformation (AMRUT)
    3. Smart City Mission
    4. Faster Adoption and Manufacturing of Hybrid and Electric Vehicles (FAME-II)
• Bharat Stage VI (BS-VI) Emission Norms:
  • BS-VI standards aim to significantly reduce vehicular pollution, lowering permissible limits for NOx and particulate matter (PM) emissions from vehicles.
• System of Air Quality and Weather Forecasting and Research (SAFAR):
  • SAFAR measures air quality and provides forecasts for metropolitan cities based on real-time data, helping authorities take preventive actions.
• Promotion of Renewable Energy:
  • India achieved a record 11% of electricity from renewable energy in 2022. However, 71% of India’s electricity still comes from coal, underscoring the need for a faster transition to cleaner energy sources.

In News:

Celebrated on 29th October 2024, marking the 9th Ayurveda Day, with the theme “Ayurveda Innovations for Global Health”.

• Global Participation: Over 150 countries participating, reflecting Ayurveda's growing global influence.
• Venue: Major events held at the All India Institute of Ayurveda (AIIA), New Delhi.

Key Highlights:

Significance of Ayurveda and its Global Outreach

• Ancient System: Ayurveda is one of the oldest healthcare systems, focusing on holistic well-being, rooted in Vedic traditions, and dating back over 5,000 years.
• Global Recognition: Recognized in 24 countries and Ayurveda products exported to over 100 countries.
• International Cooperation: Collaborative efforts through forums like BRICS, SCO, BIMSTEC, and WHO to integrate Ayurveda into global health policies.

Role of Dhanvantri in Ayurveda Day

• Dhanvantari Jayanti: Ayurveda Day coincides with Dhanteras, marking the birth anniversary of Lord Dhanvantri, considered the divine physician.
• Cultural & Religious Significance: Worshiped for promoting health and longevity, Dhanvantri symbolizes the healing powers of Ayurveda.

Innovations and Relevance of Ayurveda

• Research and Innovation: The theme emphasizes scientific advancements in Ayurveda to address global health challenges such as non-communicable diseases (NCDs), mental health, antimicrobial resistance (AMR), and geriatric care.
• Startup Ecosystem: Focus on fostering innovation through Ayurveda startups, particularly in the North Eastern states and across India.

Ayurveda’s Role in Addressing Global Health Issues

• Non-Communicable Diseases (NCDs): Ayurveda offers preventive and holistic treatment for diseases like diabetes, hypertension, and cardiovascular conditions.
• Mental Health: Ayurveda promotes balance in the mind, body, and spirit, with methods addressing stress, anxiety, and depression.
• Antimicrobial Resistance (AMR): Emphasizing traditional medicinal plants and natural remedies to combat resistance to antibiotics.
• Geriatric Health: Ayurveda's role in managing aging and enhancing quality of life through rejuvenation therapies.

Focus Areas for Ayurveda Innovation

• Women’s Health: Developing Ayurvedic solutions tailored for women's health issues, including reproductive health and hormonal balance.
• Workplace Wellness: Integrating Ayurveda in workplace settings to improve mental and physical health.
• School Wellness Programs: Promoting Ayurvedic practices in schools to boost immunity and overall health of children.
• Food Innovation: Modernizing Ayurvedic dietary concepts, focusing on nutritional balance and preventive health.

Government Initiatives and Digital Transformation

• Ayush Digital Platforms: Initiatives like Ayush Grid, Ayurgyan Scheme, Ayush Research Portal, and Namaste Portal are enhancing accessibility to Ayurvedic knowledge.
• WHO Integration: Ayurveda's inclusion in the WHO ICD-11 Traditional Medicine Module facilitates global standardization and recognition.
• I Support Ayurveda Campaign: A public awareness campaign aiming to garner over 250 million votes in support of Ayurveda.

Ayurvedic Education and Research

• Research Centers: Government-supported centers like the Research Centre for Innovation in Ayurveda Biology and WHO Global Traditional Medicine Centre advancing Ayurveda's global integration.
• Academic Contributions: Institutes like National Institute of Ayurveda, Institute of Teaching and Research in Ayurveda, and North Eastern Institute of Ayurveda and Homeopathy are leading innovation and education in Ayurveda.

Ayurveda and Sustainable Development Goals (SDGs)

• SDG 3 (Good Health and Well-being): Ayurveda contributes significantly to public health, with a focus on preventive care and holistic health.
• Universal Health Coverage (UHC): Ayurveda supports affordable, accessible healthcare solutions, complementing the global health agenda.

In News:

• On October 27, 2024, prominent landmarks such as Rashtrapati Bhawan, Parliament House, India Gate, and the North and South Blocks in Delhi were illuminated in red to raise awareness for Dyslexia and other learning disabilities.
• Similar illuminations took place in major cities like Patna, Ranchi, Jaipur, Kohima, Shimla, and Mumbai, highlighting the importance of dyslexia awareness.

Key Highlights:

• Collaboration for Awareness:
  • The campaign is organized in collaboration with UNESCO Mahatma Gandhi Institute of Education for Peace and Sustainable Development (MGIEP) and the ChangeInkk Foundation.
  • Its goal is to remove stigma and foster understanding of dyslexia and other learning disabilities, which affect 20% of India’s population—around 35 million students.
• Flagging off the ‘Walk4Dyslexia’:
  • The ‘Walk4Dyslexia’ event, aimed at promoting collective action for dyslexia awareness, was flagged off by Shri Rajesh Aggarwal, Secretary of the Department of Empowerment of Persons with Disabilities (DEPwD), along with Mr. Shombi Sharp, UN Resident Coordinator in India.
  • The walk was organized by ChangeInkk Foundation, UNESCO MGIEP, Orkids Foundation, and Soch Foundation.
• Growth of the Campaign:
  • The Act4Dyslexia campaign saw a significant expansion in 2024, with over 1,600 walks held across the country, from state capitals to villages, engaging over 4 lakh participants.
  • The campaign mobilized 2 billion steps in support of dyslexia awareness, with 150+ organizations joining forces.
• Focus on Equal Rights and Opportunities:
  • Dyslexia and other specific learning disabilities (SLDs) were officially recognized under the Rights of Persons with Disabilities Act, 2016. This law mandates equal educational and employment opportunities for individuals with disabilities.
  • The National Education Policy (NEP) 2020 further emphasizes inclusive education, calling for early identification, teacher capacity building, and necessary support and accommodations.
• Understanding Dyslexia:
  • Dyslexia is often misunderstood as a sign of being a "slow learner", but people with dyslexia often excel in areas like logical reasoning, problem-solving, and innovation.
  • Notably, 40% of self-made millionaires have dyslexia, and historical figures like Albert Einstein were also dyslexic.
• Global Impact:
  • The campaign aligns with the Sustainable Development Goals (SDGs), aiming to unlock the untapped potential of individuals with learning disabilities, thereby contributing to societal development at a global level.

In News:

Precision medicine is bringing in a new era of personalised healthcare. The field began to take concrete shape when scientists were wrapping up the Human Genome Project.

Introduction to Precision Medicine:

• Precision Medicine is a novel approach to healthcare that tailors treatments and preventive strategies based on an individual’s genetics, environment, and lifestyle, instead of using a one-size-fits-all approach.
• It leverages technologies like genomics, gene editing (CRISPR), and mRNA therapeutics to address various diseases such as cancer, chronic diseases, and genetic disorders.
• Recent breakthroughs include gene therapy for restoring vision and stem cell transplants for reversing diabetes, demonstrating the transformative potential of precision medicine.

Role of Biobanks in Precision Medicine:

• Biobanks are repositories storing biological samples (blood, DNA, tissues) along with associated health data. These samples are crucial for research and development of personalized treatments.
• Large and diverse biobanks are essential for ensuring that precision medicine benefits a wide demographic, as data from homogenous groups could limit the applicability of findings.
• Recent studies using biobank data have led to breakthroughs, such as identifying rare genetic disorders and developing organoid models for high-throughput drug screening.

Precision Medicine and Biobanks in India:

• Market Growth: India’s precision medicine market is growing at a CAGR of 16%, expected to surpass USD 5 billion by 2030, contributing 36% to the national bioeconomy.
• Policy Framework: The government’s BioE3 policy aims to promote biomanufacturing, with a focus on precision therapeutics and related technologies like gene editing and cancer immunotherapy.
• Biobank Initiatives:
  • Genome India Programme: Completed sequencing of 10,000 genomes from 99 ethnic groups, aimed at identifying treatments for rare genetic diseases.
  • Phenome India Project: Focused on collecting 10,000 samples for improving prediction models for cardio-metabolic diseases.
  • Paediatric Rare Genetic Disorders (PRaGeD) Mission: Aiming to identify genes that could help develop targeted therapies for genetic diseases in children.

Regulatory and Ethical Challenges in Biobanking:

• India’s biobanking regulations are inconsistent, hindering the full potential of precision medicine. Unlike countries like the U.K., U.S., and Japan, which have comprehensive laws addressing issues like informed consent, data protection, and privacy, India lacks a cohesive regulatory framework.
• Informed Consent Issues: In India, participants provide samples without full knowledge of how their data will be used, who will have access to it, and for how long it will be stored. This lack of transparency undermines public trust in biobank research.
• Ethical Concerns: Without a clear regulatory framework, there is a risk of misuse of biological samples, such as non-consensual data sharing and sample mishandling.
• International Implications: The absence of robust laws allows foreign pharmaceutical companies to access Indian biobank data and samples without ensuring that the Indian population benefits from the resulting research or profits.

Global Comparison of Biobank Regulations:

• International Standards: Countries like the U.K., U.S., and Japan have established comprehensive biobank regulations, addressing:
  • Informed consent for sample collection and data usage.
  • Privacy protection and secure storage of genetic information.
  • Withdrawal rights for participants at any stage of research.
• India’s biobank regulations lack clear provisions for data protection and participant rights, limiting the effectiveness of research and undermining public confidence in biobanks.

In News:

• An E. coli outbreak has been linked to McDonald's burgers in the United States. The infection has affected at least 10 states.

E. coli in India:

• Prevalence: E. coli infections are common in India, especially during the summer and rainy seasons, when there is an increase in gastrointestinal infections.
• Transmission: E. coli spreads mainly through contaminated food and water.
• National statistics: Over 500 outbreaks of diarrhoeal diseases were reported in India in 2023. E. coli is one of the most common pathogens causing gastrointestinal infections in India.
• ICMR data: According to the latest report from the Indian Council of Medical Research (ICMR), E. coli was found in 23.19% of patient samples from tertiary care hospitals across India.
• FSSAI's Role: The Food Safety and Standards Authority of India (FSSAI) is establishing a network of 34 microbiology labs to test food for pathogens like E. coli, salmonella, and listeria.

Symptoms of E. coli Infection:

• Common symptoms include:
  • High fever (over 102°F)
  • Persistent diarrhoea, sometimes bloody
  • Vomiting
  • Dehydration due to fluid loss
• Severe cases may lead to acute kidney injury.

Treatment of E. coli Infections:

• E. coli is treated with antibiotics, but medical consultation is necessary before taking any medication.
• Antimicrobial resistance is a growing concern, as E. coli's susceptibility to antibiotics, including carbapenem, has declined from 81.4% in 2017 to 62.7% in 2023.

When to Seek Medical Attention:

• Consult a doctor if:
  • Diarrhoea lasts more than a couple of days.
  • Frequent visits to the toilet (every half hour to an hour).
  • Bloody diarrhoea.
  • Vomiting frequently or inability to retain fluids.

Food Safety Measures:

• The FSSAI is working to improve food safety by implementing better testing protocols for microbial contamination in food products across India.

In News:

• The World Health Organization (WHO) has listed the Alinity m MPXV Assay under its Emergency Use Listing (EUL) procedure.
• The test, developed by Abbott Molecular Inc., will help expand diagnostic capacity in countries experiencing Mpox outbreaks, particularly in Africa.
• Importance of Early Diagnosis:
• Early diagnosis enables timely treatment and virus control.
• It is critical for improving Mpox surveillance, especially in areas with high transmission.

Current Mpox Situation

• Global Context:
  • Over 30,000 suspected cases reported in Africa in 2024.
• India has reported 30 cases since the WHO declared Mpox a global health emergency in August 2024.
• Testing Capacity:
• Limited testing capacity and delays in confirming cases have been a significant barrier to controlling the spread, especially in Africa.
• In India, 35 laboratories are currently equipped to test suspected Mpox cases.

Mpox Diagnostic Test Details

• Alinity m MPXV Assay:
• A real-time PCR test that detects monkeypox virus (MPXV) DNA from skin lesion swabs.
• Used by trained clinical laboratory personnel proficient in PCR techniques.
• Helps confirm suspected Mpox cases from pustular or vesicular rash samples.
• WHO's Role:
• The Emergency Use Listing (EUL) procedure accelerates the availability of life-saving products during public health emergencies.
• WHO aims to increase access to quality-assured diagnostics in regions most affected by Mpox.

About Mpox

• What is Mpox?
• Zoonotic disease caused by the monkeypox virus, part of the Orthopoxvirus genus (family Poxviridae).
• Closely related to smallpox, but generally less severe in humans.
• Transmission:
• Spread via physical contact with infected lesions, body fluids, or contaminated materials.
• Can also spread through animal bites, or activities like hunting, skinning, or eating infected animals.
• Two Clades:
• Clade I: Predominantly in Central and East Africa.
• Clade II: More common in West Africa; linked to the 2022 outbreak.
• Symptoms:
• Rashes, blisters, fever, sore throat, headache, muscle aches, back pain, swollen lymph nodes.
• Lesions typically scab over as they heal.
• Most people experience mild symptoms, but children, pregnant women, and immunocompromised individuals are at greater risk.

Treatment and Prevention

• No Specific Cure:
• Supportive care (e.g., pain relief, hydration) is recommended.
• In some cases, antivirals like tecovirimat (developed for smallpox) may be used under exceptional circumstances.
• Vaccination:
• Three smallpox vaccines are recommended for at-risk individuals: MVA-BN, LC16, and OrthopoxVac.
• Mass vaccination is not recommended by WHO.

In News:

India to seek WHO certification for eliminating disease.

Overview of Kala-Azar (Visceral Leishmaniasis)

• Cause: Kala-azar is caused by the protozoan parasite Leishmania donovani, transmitted by the bite of infected female sandflies (Phlebotomus argentipes in India).
• Symptoms: Includes irregular fevers, weight loss, swelling of the spleen and liver, severe anaemia. If untreated, it is fatal in over 95% of cases.
• Affected Areas: Historically, Bihar, Jharkhand, West Bengal, and parts of Uttar Pradesh report the highest number of cases, with Bihar alone accounting for over 70% of India's cases.

India's Achievement in Kala-Azar Control

• Current Status:
  • India has managed to maintain Kala-azar case numbers below 1 per 10,000 population for two consecutive years.
  • This meets the WHO's criteria for elimination certification.
• 2023 and 2024 Statistics:
  • 2023: 595 cases and 4 deaths.
  • 2024 (so far): 339 cases and 1 death.

WHO Certification for Elimination

• WHO's Target: The World Health Organization aims to eliminate Kala-azar as a public health problem by 2030.
• Elimination Criteria: A country can be certified when:
  • Local transmission is interrupted for a specified period.
  • There is a system in place to prevent re-emergence of the disease.
• Global Context: Bangladesh is the first country to have eliminated Kala-azar, receiving WHO certification in October 2024, after reporting fewer than 1 case per 10,000 people for three consecutive years.

India's Kala-Azar Elimination Strategies

• National Health Policy (2002): Initially set the target to eliminate Kala-azar by 2010, revised multiple times, and is now aiming for 2030.
• Key Strategies:
  • Active Case Detection: Identification and treatment of all cases.
  • Vector Control: Targeting sandfly breeding grounds through insecticides and environmental management.
  • Community Awareness: Educating the public on disease prevention and early diagnosis.
  • Improved Surveillance: Ensuring rapid diagnosis and treatment access, including the use of the rK39 diagnostic kit.
  • Integrated Vector Management: Combining insecticide spraying with environmental changes to reduce sandfly populations.

Challenges and Areas of Focus

• Root Causes: Persistent issues like poverty, inadequate sanitation, and malnutrition contribute to the spread of Kala-azar, particularly in rural, impoverished areas.
• Long-term Solutions:
  • Strengthen vector control and improve sanitation.
  • Address socio-economic factors like poverty and displacement.
  • Invest in research for vaccines and new treatments.

Public Health Impact and the Way Forward

• Elimination Milestone: If India continues to reduce cases, it will join Bangladesh in eliminating Kala-azar as a public health threat.
• Sustaining Gains:
  • Surveillance and quick response to new cases remain critical.
  • Expand access to rapid diagnostic tools and effective anti-parasitic treatments.
  • Focus on inter-sectoral convergence, integrating efforts from various government sectors, including health, sanitation, and housing.

In News:

• Jipmer (Jawaharlal Nehru Institute of Postgraduate Medical Education and Research) has launched the "Tele-MANAS" (Tele Mental Health Assistance and Networking Across States) helpline, a toll-free service (14416) aimed at providing mental health support.
• This initiative is part of the National Tele Mental Health Programme (NTMHP), launched by the Union Ministry of Health and Family Welfare.

Purpose and Need:

• With an estimated 1 in 10 people in India suffering from mental illness, and about 1% experiencing severe conditions, the service addresses significant gaps in mental health access, particularly in rural and remote areas.
• The helpline aims to provide immediate support for issues such as anxiety, depression, and emotional distress.

Training and Operations:

• Jipmer will train qualified counsellors who will subsequently train additional counsellors to expand the reach of the service.
• Counselors will be available 24/7, including holidays, to ensure continuous support.

Support Structure:

• Trained counselors will serve as the first point of contact for individuals seeking help, providing responses, suggestions, and necessary referrals to advanced mental health facilities.
• Jipmer will supervise the program, ensuring regular retraining and maintaining service quality.

Integration with National Programs:

• The initiative is coordinated by the National Institute of Mental Health and Neuro Sciences (NIMHANS), which acts as the National Apex Centre for the NTMHP.
• It includes a comprehensive information library on mental health and guidance for managing early signs of stress and emotional challenges.

Impact on Mental Health Services:

• The program aims to enhance the overall quality of mental health services across states and union territories in India, making them more accessible to a larger population.
• Emphasizes the importance of mental health as a public health priority.

In News:

The World Health Organization (WHO) has now recognised that India has successfully eliminated trachoma, a bacterial infection that affects the eyes, as a public health problem.

WHO Declaration:

• India has eliminated Trachoma as a public health problem (2024).
• Third country in the South-East Asia Region to achieve this milestone.

Trachoma Overview:

• Bacterial infection caused by Chlamydia Trachomatis.
• Contagious; spreads through contact with infected secretions.
• Can lead to irreversible blindness if untreated.
• Considered a neglected tropical disease.

Global Impact:

• WHO estimates 150 million affected worldwide; 6 million at risk of blindness.
• Most prevalent in underprivileged communities with poor living conditions.

Historical Context in India:

• Leading cause of blindness in the 1950s-60s.
• National Trachoma Control Program launched in 1963.
• Control efforts integrated into the National Program for Control of Blindness (NPCB).

Statistics:

• Blindness due to Trachoma was 5% in 1971; now reduced to less than 1%.
• Implementation of the WHO SAFE strategy (Surgery, Antibiotics, Facial hygiene, Environmental cleanliness).

Milestones:

• India declared free from infective Trachoma in 2017.
• Continued surveillance for cases from 2019 to 2024.

National Trachomatous Trichiasis (TT) Survey:

• Conducted in 200 endemic districts (2021-2024) under NPCBVI.
• Mandated by WHO to confirm elimination status.

In News:

India Participates in 44th Session of Codex Committee on Nutrition and Foods for Special Dietary Uses

Key Contributions:

• Nutrient Reference Values:
  • Advocated for reference values for ages 6 to 36 months.
  • Suggested combining NRV-R values by averaging those for 6-12 months and 12-36 months.
  • This proposal was accepted by the committee.
• Probiotic Guidelines:
  • Emphasized the need to update FAO/WHO probiotic guidelines, which are two decades old.
  • Highlighted the lack of international harmonization in probiotic regulations affecting global trade.
  • Committee agreed to revisit guidelines and requested FAO and WHO to conduct a literature review on probiotics.
• Discussion on Sweetness Assessment:
  • Disagreed with the EU’s sensory testing proposal for carbohydrate sources in Follow-up Formula, citing lack of scientific validation.
  • Supported by USA, Canada, and others; this led to the committee discontinuing the topic for now.
  • Noted that ISO 5495 or other methods could be used in the absence of harmonized methods.
• Delegation:
  • Included representatives from the Food Safety and Standards Authority of India, Ministry of Health and Family Welfare, and Ministry of Women and Child Development.
  • Advocated for various food safety, consumer health, and trade-related issues.
• Outcome:
  • India’s suggestions were officially incorporated into the final report, significantly influencing global food safety and nutrition standards.
• Additional Announcements:
  • FAO/WHO plans for a Joint Statement on Healthy Diet Principles.
  • Updates on reviewing benefits and risks of Alternative Animal Source Foods (A-ASFs).
  • FAO introduced a new “Food and Diet” domain on its FAOSTAT database.

Overview

India’s mental healthcare landscape is evolving, with increasing awareness and decreasing stigma around mental health issues. However, access to mental healthcare remains a significant challenge due to a shortage of professionals. Here are the key points:

Current State of Mental Healthcare in India

1. Rising Demand: Shifts in societal attitudes have led to more individuals seeking mental health support. Awareness and willingness to access treatment have notably increased.
2. Professional Shortage: Despite the rising demand, there are only 0.75 psychiatrists per one lakh population, far below the World Health Organization’s recommendation of three per lakh. As of the latest data, India has about 9,000 psychiatrists, while an estimated 36,000 are needed to meet the standard.
3. Slow Workforce Growth: Approximately 1,000 psychiatrists enter the workforce annually, but with attrition and unemployment, it could take around 27 years to reach the WHO target without intervention.
4. Comparative Analysis: India has one of the lowest psychiatrist-to-population ratios among BRICS nations, trailing only Ethiopia. However, it performs better than many South Asian countries.

Limitations of Current Data

1. Outdated Survey: The data largely relies on the National Mental Health Survey (NMHS) conducted between 2015 and 2016, which is based on a limited sample size of around 40,000 people across 12 states.
2. Narrow Focus: The NMHS primarily addressed specific mental illnesses and overlooked milder conditions, emotional issues, and vulnerable populations like prisoners and the homeless.
3. Need for Updated Research: A second NMHS is scheduled for release next year, which may provide more comprehensive data and insights.

Improvements in Awareness and Attitudes

1. Positive Attitudinal Shift: A study by the LiveLoveLaugh Foundation found significant improvements in how Indians perceive mental health. For instance, the percentage of people believing that individuals with mental illnesses can handle responsibilities rose from 32% in 2018 to 65% in 2021.
2. Willingness to Seek Help: Over 90% of respondents in 2021 indicated they would seek treatment for themselves or support others in doing so, a substantial increase from 54% in 2018.
3. Increased Awareness: Awareness of mental health issues has grown, with 96% of respondents in 2021 recognizing mental health compared to 87% in 2018.

Conclusion

While India is making strides in reducing stigma and increasing awareness around mental health, the critical shortage of mental health professionals poses a significant barrier to accessing timely care. Addressing this issue requires targeted policy interventions and incentives to boost the supply of mental health professionals and improve the overall infrastructure for mental healthcare in the country.

In News:

• Union Minister of State for Health and Family Welfare, represented India at the G20 Joint Finance-Health Task Force meeting during the 79th UN General Assembly.
• Focus: The session emphasized the importance of investing in health and addressing social determinants of health (SDH) through initiatives like debt-for-health swaps.

Key Highlights:

• Role of SDH: Underscored how social determinants such as housing, sanitation, water access, and income security are crucial for health investment priorities.
• Flagship Programs: India’s notable initiatives include:
  • Ayushman Bharat: The world’s largest health insurance scheme.
  • Swachh Bharat Mission: Aiming for a cleaner India.
  • Jal Jeevan Mission: Ensuring water access for all.
  • Pradhan Mantri Awas Yojana: Promoting housing for all.
• Impact of PM-JAY: Highlighted improvements in access to healthcare and outcomes, especially for non-communicable diseases.

Data and Policymaking

• Importance of Data: Stressed the need for enhanced data availability and standardization on SDH indicators to support effective policymaking.
• Unified Approach: Called for G20 nations to collaborate on data collection and analysis for better health systems globally.

Exploring Debt-for-Health Swaps

• Potential Mechanism: Discussed debt-for-health swaps as a means to relieve financial pressure while promoting health equity.
• Next Steps: Emphasized the need for stakeholder engagement and pilot programs to ensure effective implementation.

Conclusion

• Global Leadership: India reaffirmed its commitment to health equity through evidence-based policies and partnerships.
• Shared Vision: Advocated for a unified effort towards achieving “Health for All,” highlighting the significance of investments in social determinants of health.

About Social determinants of health (SDOH)

• SDOH are non-medical factors that affect a person's health, well-being, and quality of life. They include the conditions in which people are born, grow, work, live, and age. 
• SDOH also include the broader systems that shape everyday life, such as economic policies, social norms, and political systems. 
• Some examples of SDOH include:
  • Safe housing, transportation, and neighborhoods
  • Racism, discrimination, and violence
  • Education, job opportunities, and income
  • Access to nutritious foods and physical activity opportunities
  • Polluted air and water
  • Language and literacy skills

In News:

Jordan has made history by becoming the first country in the world to be officially verified by the World Health Organization (WHO) as having eliminated leprosy. This achievement marks a significant advancement in global public health efforts.

Key Highlights:

• WHO Recognition: WHO Director-General Dr. Tedros Adhanom Ghebreyesus praised Jordan for this milestone, emphasizing the importance of stopping transmission and alleviating the suffering and stigma associated with leprosy.
• Historic Achievement: This success is not just about disease elimination but also about combating stigma and socio-economic harm.
• No Local Cases: Jordan has not reported any locally transmitted cases of leprosy for over two decades, demonstrating its effective public health strategies and strong political commitment.
• Independent Verification: WHO commissioned an independent team to conduct a thorough assessment, leading to the official recognition of leprosy elimination.
• Ongoing Vigilance: While celebrating this success, both the WHO and the Jordanian Ministry of Health emphasize the need for robust surveillance systems to detect and manage any future cases, including those from abroad.

Additional Context:

Leprosy, or Hansen's disease, is a chronic infectious condition caused by Mycobacterium leprae, primarily affecting the skin and nerves. Although it remains a neglected tropical disease, with over 200,000 new cases reported annually across more than 120 countries, Jordan's success showcases the potential for eradication through dedicated efforts.

This milestone serves as a beacon of hope, illustrating that with strong commitment, collaboration, and strategic planning, even longstanding public health challenges can be addressed effectively.

In News:

The Ministry of Women and Child Development recently earned the National Award for e-Governance 2024 (Gold) for its Poshan Tracker initiative, which has made significant strides in enhancing child health and nutrition.

About the Poshan Tracker Initiative

The Poshan Tracker initiative focuses on identifying and addressing growth-related issues in children aged 0-6 years. By using real-time monitoring and WHO growth charts, the program ensures that children receive optimal nutrition.

Key components of the initiative include:

• Role of Anganwadi Workers (AWWs): These workers are essential in assessing children's health and implementing necessary interventions when deviations from expected growth are observed.
• Technology Integration: The program employs advanced ICT tools and Growth Measuring Devices (GMD) at Anganwadi Centers (AWCs) to enable precise data collection and regular monitoring.
• Impact: Real-time growth monitoring through the Poshan Tracker has substantially improved child health outcomes in India, benefiting millions of children under the Mission Poshan 2.0 initiative.

Key Features of the Poshan Tracker App

• Comprehensive Overview: The app offers a complete view of Anganwadi Centre activities, including service deliveries and beneficiary management for pregnant women, lactating mothers, and children under six.
• Digitization and Automation: It replaces physical registers used by workers with digital records, thereby enhancing the quality and efficiency of their work.
• Smartphone Provision: Anganwadi workers have been provided with smartphones through the Government e-Market (GeM) to streamline service delivery.
• Technical Support: Each state has a designated nodal person to provide technical assistance and resolve issues related to the Poshan Tracker application.
• Service Accessibility: Migrant workers who registered in their original state can access services at the nearest Anganwadi in their current location.

In News:

Union Minister of State for Women and Child Development, launched the Rashtriya Poshan Maah 2024 in Dhar district of Madhya Pradesh on 1st September,2024.

Key Highlights:

• As part of the 7th Rashtriya POSHAN Maah, awareness programs are being organized at various levels.
• Under the ICDS (Integrated Child Development Services) Project, complementary feeding activities were conducted at Anganwadi Centres (AWC) Paduck Bagicha, South Andaman.
• Also, at AWC, Champin Nancowrie, Nicobar district (Andaman & Nicobar) under the ICDS Tribal initiative, local food items and nutrition sources were displayed.
• These efforts aim to further the Prime Minister's vision of a ‘Suposhit Bharat’ by conducting diverse large-scale activities, harnessing the potential of Gram Panchayats and Urban Local Bodies.

Rashtriya Poshan Maah:

• The programme is annually celebrated in the month of September, with a different theme each year, primarily focusing on addressing malnutrition by ensuring convergence of various nutrition-related schemes and programmes.
• The objective of the Poshan Maah is to ensure community mobilisation and bolster people’s participation for addressing malnutrition amongst young children, and women and to ensure health and nutrition for everyone.

Poshan Abhiyaan:

• POSHAN Abhiyan (Prime Minister's Overarching Scheme For Holistic Nourishment) focuses on advancing nutritional outcomes for children under six years, adolescent girls, pregnant women, and lactating mothers.
• To cultivate widespread awareness about nutrition at each stage of life, it is celebrated annually as Poshan Maah (1st—30th September) and Poshan Pakhwada (fortnight of March).
• POSHAN Abhiyan (National Nutrition Month) aims to strengthen efforts to end hunger and malnutrition.
• It focuses to improving the nutritional outcomes among children, adolescent girls, pregnant women, and lactating mothers by focusing on prenatal care, diet, and optimal breastfeeding.
• The Ministry of Women and Child Development plans month-long activities under Poshan Maah, focusing on issues such as the hygiene and sanitation, anaemia prevention, maternal and infant health, among others.
• There are outreach programmes, identification drives, camps, and fairs with a special focus on pregnant and lactating women, children below six years, and adolescent girls in order to realise the vision of ‘Swasth Bharat’.

The recent approval of the BPaLM regimen by India's Union Health Ministry marks a significant advancement in the fight against multidrug-resistant tuberculosis (MDR-TB). This new treatment combines four drugs—Bedaquiline, Pretomanid, Linezolid, and Moxifloxacin—and offers several benefits over traditional treatments.

Key Points:

1. Enhanced Effectiveness: The BPaLM regimen has demonstrated a higher efficacy in treating MDR-TB compared to previous methods.
2. Shorter Treatment Duration: Unlike traditional treatments, which can take up to 20 months and often come with severe side effects, the BPaLM regimen shortens the treatment period to just six months.
3. Improved Safety: The new regimen is noted for its safety profile, potentially reducing the risk of adverse effects compared to older treatments.
4. Cost Savings: By shortening the treatment duration and improving outcomes, the BPaLM regimen is expected to lower overall treatment costs.
5. Integration into National TB Elimination Programme: This regimen will be incorporated into India’s National TB Elimination Programme, aligning with the country’s ambitious goal to eliminate TB by 2025, which is five years ahead of the global target.
6. Infrastructure and Testing Facilities: India boasts a comprehensive TB laboratory network, including 7,767 rapid molecular testing facilities and 87 culture and drug susceptibility testing laboratories, which will support the implementation of the new regimen.

This development represents a significant step forward in TB care and aligns with broader global efforts to combat drug-resistant TB more effectively.

Why is it in the News?

The World Health Assembly will convene from May 27 to June 1 to discuss amendments to the International Health Regulations, aimed at improving the ability of countries to respond to public health emergencies and prepare a potential new pandemic agreement.

What is the World Health Assembly?

• The World Health Assembly is the decision-making body of the World Health Organization (WHO), the United Nations (UN) agency dedicated to promoting the global population's health and access to the highest levels of healthcare provision.
• Its main functions are to determine WHO's policies, elect the Organization's Director-General, supervise financial policies, and review and approve the proposed WHO budget.
• Delegates from WHO member states come together at an annual assembly held at the UN headquarters in Geneva, Switzerland, to focus on a specific healthcare agenda created by the organization's Executive Board.
• The Executive Board comprises 34 technically qualified members, each elected for a three-year term.
  • They meet every year in January to agree on the agenda and any resolutions that will be put before the World Health Assembly for consideration.
• Now in its 76th session, the theme for this year’s event is “Health For All: 75 Years of Improving Public Health”.

What does the Assembly do?

• Delegates at the annual World Health Assembly discuss the Executive Board's policy agenda for the coming year and decide which health goals and strategies will guide the WHO's public health work.
• Other functions include voting to appoint the organization's Director-General to serve a five-year term.
  • Dr Tedros Adhanom Ghebreyesus holds the post currently, having been re-elected in 2022 to serve a second term as head of the world's leading public health agency.

Why is it important?

• Since its inauguration, the Assembly has presided over WHO policies that have helped eradicate deadly diseases like smallpox and the poliovirus and helped foster international collaborations to develop and distribute vaccines for diseases like malaria and COVID-19.

About International Health Regulations (IHR):

• First adopted by the World Health Assembly (WHA) in 1969, the IHR was last revised in 2005. These regulations aim to maximize collective efforts in managing public health events while minimizing disruptions to travel and trade.
• The IHR has 196 State Parties, including all 194 WHO Member States, plus Liechtenstein and the Holy See.
• The IHR provide a comprehensive legal framework that outlines countries' rights and obligations in managing public health events and emergencies with the potential to cross borders.
• The regulations introduce crucial safeguards to protect the rights of travellers and others, covering the treatment of personal data, informed consent, and non-discrimination in the application of health measures.
• Legally Binding Instrument: As an instrument of international law, the IHR is legally binding on 196 countries.

Why is it in the News?

The Widal test's tendency to produce inaccurate results is clouding the understanding of India's typhoid burden, leading to increased costs, and exacerbating antimicrobial resistance risks.

What is the Widal Blood Test?

• A Widal test is a serological diagnostic test for typhoid fever.
• It helps evaluate the level of antibodies produced by the body in response to the Salmonella bacterial infection that causes typhoid fever in patients.
• Widal blood test is also known as a typhoid blood test report, as it is widely used for diagnosing typhoid fever.
  • The symptoms of typhoid fever may be similar to those of other diseases, which can make the diagnosis of typhoid difficult without proper testing.
• Typhoid fever is a severe illness caused by a bacterium called Salmonella Typhi.
• This bacterium affects the gastrointestinal system and causes a range of symptoms such as high fever, diarrhoea or constipation, headache, abdominal pain, fatigue, weight loss, and red spots.
• The bacteria usually enter the body through contaminated food or water.
  • Typhoid requires prompt treatment to prevent further complications such as severe intestinal perforation or bleeding.
• The Widal blood test is a quick and easy serological test that can help confirm or rule out whether a fever is due to a typhoid infection.
• Typically, typhoid symptoms appear within 6 to 30 days of exposure to the bacterial infection.
• The Widal test is designed to detect antibodies against O (somatic) and H (flagellar) antigens that cause the infection and typhoid fever.
• Infection through these antigens produces specific antibodies in response.
• The Widal blood test analyses the interaction between these two antigens and the antibodies produced in the patient's body through a blood sample.
  • Detecting the presence of these antibodies in the Widal blood test indicates a bacterial infection.
• However, it has several limitations and has been phased out in many countries due to its potential for inaccuracy.
• The World Health Organization (WHO) advises against relying heavily on the Widal Test because various factors can influence its results.
  • For example, a single positive result does not definitively confirm an active typhoid infection and a negative result does not necessarily rule it out.
• Additionally, obtaining an accurate diagnosis requires testing at least two serum samples taken 7-14 days apart, which can be time-consuming and often impractical.
• In areas with a continuous high burden of typhoid, baseline antibody levels may already be elevated, complicating the interpretation of results without knowing the appropriate cut-off values.
  • Furthermore, cross-reactivity with antibodies produced against other infections or vaccinations can lead to false positives.
  • Prior antibiotic therapy can also impact antibody levels, resulting in false negatives.
• Despite its accessibility and historical significance, the Widal Test's limitations emphasize the need for more accurate and reliable diagnostic methods for typhoid fever.

Why is it in the News?

The Kerala health department has issued an alert after cases of West Nile fever were reported in Malappuram, Kozhikode and Thrissur districts.

What is West Nile Fever?

• West Nile Fever is a viral infection transmitted primarily by mosquitoes, caused by the West Nile virus (WNV).
• The virus is commonly found in Africa, Europe, the Middle East, North America, and West Asia.
• Most people infected with the West Nile virus don’t experience any symptoms.
  • About 20% of people who become infected with WNV will develop West Nile fever.
• However, for some, particularly the elderly or those with weakened immune systems, symptoms can range from mild flu-like symptoms such as fever, headache, body aches, fatigue etc.
• Transmission occurs when mosquitoes become infected after feeding on infected birds, and then bite humans.

Why is it named West Nile Fever?

• West Nile Virus was first isolated in a woman in the West Nile district of Uganda in 1937.
• According to the World Health Organisation (WHO), It was identified in birds in the Nile Delta region in 1953,

Symptoms:

• West Nile Fever can manifest with a range of symptoms, although the majority of individuals infected with the West Nile virus (WNV) remain asymptomatic.
• For those who do exhibit symptoms, they typically appear within 2 to 14 days after being bitten by an infected mosquito.
• Common symptoms include fever, headache, body aches, and fatigue, which are similar to those of the flu.
  • Additionally, individuals may experience nausea, vomiting, diarrhoea, and swollen lymph glands.
  • Skin rash and swollen joints are also reported in some cases.
• In more severe instances, West Nile Fever can lead to neurological complications.
  • These may include meningitis (inflammation of the membranes surrounding the brain and spinal cord) or encephalitis (inflammation of the brain).
  • Signs of neurological involvement may include severe headache, high fever, neck stiffness, disorientation, tremors, seizures, paralysis, and coma.

Treatment:

• While there is no specific treatment for West Nile Fever, supportive care such as pain management, fluids, and rest can help alleviate symptoms and aid recovery.
• Prompt medical attention is crucial, especially for those experiencing neurological symptoms, as these can be life-threatening.

Why is it in the News?

Centre for Cellular and Molecular Platforms (C-CAMP) has joined the Blockchain for Impact (BFI) Biome Virtual Network Program to accelerate transformative healthcare solutions through biomedical innovation.

About BFI Biome Virtual Network Program:

• The BFI-Biome Virtual Network Program is a pioneering initiative uniting incubators and research institutes under a single umbrella.
• This fosters collaborations among the stakeholders in the translational pipeline, the process of transforming research discoveries into real-world applications.
• Through this program, BFI will allocate over 200,000 USD over the course of three years, leveraging C-CAMP’s expertise to develop essential programs for healthcare-based startups.
• C-CAMP being an organization to foster deep science research and innovation for societal impact, the goals and mandates of both partners naturally align and complement each other.
• The partnership is expected to blur disciplinary boundaries in approaching biotech R&D, promote cross-integration of expertise and infrastructure, and provide multidisciplinary insights into need identification, problem-solving, and solution implementation.

What is C-CAMP?

• Centre for Cellular And Molecular Platforms (C-CAMP) is an initiative of the Dept of Biotechnology, Ministry of Science and Technology, Govt. of India, with a mandate to be an enabler of cutting edge Life Science Research and Innovation.
• C-CAMP is also a member of the Bangalore Life Sciences Cluster (BLiSC).
• It facilitates Bioscience Research and Entrepreneurship by providing Research, Development, Training, and Services in state-of-the-art Technology Platforms.
• As a part of C-CAMP's mandate of promoting entrepreneurship and innovation, C-CAMP has created and fostered an entrepreneur-friendly culture in and around the Academic/Research environment through its involvement in Seed Funding Schemes for Startups, Entrepreneur Mentorship program, and Bio-Incubation facility.
• It has established State-Of-The-Art Platform Technologies which are essential requirements for success and leadership in the field of Life Sciences.
• C-CAMP allows Investigators to use Techniques as tools and not be limited by Technological barriers while pursuing challenging scientific questions.

Why is it in the News?

Recently, the government has launched the 'myCGHS' app for iOS to provide Central Government Health Scheme beneficiaries access to electronic health records, information, and resources.

About myCGHS app:

• The Union Health Ministry launched the myCGHS app for iOS (Apple Users) to provide easy access for the Central Government Health Scheme (CGHS) beneficiaries to their Electronic Health Records, information, and other resources.
• The myCGHS iOS app is developed by the technical teams of the National Informatics Centre (NIC) Himachal Pradesh and the NIC Health Team.
• It is a convenient mobile application offering features aimed at enhancing information and accessibility for CGHS beneficiaries.
• The app is said to offer a range of services including:
  • Online appointment booking and cancellation
  • Downloading CGHS card and index card
  • Accessing lab reports from CGHS labs
  • Checking medicine history
  • Monitoring medical reimbursement claim status
  • Accessing referral details
  • Locating nearby wellness centers
  • Staying updated with news and highlights, and
  • Finding nearby impaneled hospitals, labs, and dental units.
• Additionally, users can access the contact details of wellness centers and offices conveniently.
• To ensure data security, the app also features security measures such as two-factor authentication and mPIN function to be able to access the app once they are logged in.
• Users on the Apple ecosystem can find the app on the App Store and download it free of charge.
• The myCGHS app has been available for Android users since February 2022.

Key Highlights of the Central Government Health Scheme (CGHS):

• CGHS provides healthcare services to registered employees and pensioners of the Central Government of India.
• Enrolled members receive reimbursement and cashless healthcare facilities through this scheme.
• It encompasses healthcare services from various systems of medicine including Allopathy, Homeopathy, Ayurveda, and Unani.
• CGHS beneficiaries have the flexibility to undergo treatment at any impaneled private hospital of their preference.

Why is it in the News?

The World Health Organization (WHO) has launched a global network of laboratories to identify and monitor potentially novel coronaviruses that could emerge shortly.

What is CoViNet?

• The Coronavirus Network (CoViNet) is a global collaboration of laboratories with expertise in human, animal, and environmental coronavirus surveillance.
  • This network aims to identify and monitor potential new coronaviruses that could emerge and impact public health worldwide.
• To enhance pandemic preparedness, CoViNet will expand its scope to include animal health and environmental surveillance, as well as timely risk assessments.
  • This will allow the World Health Organization (WHO) to develop more informed policies and protective measures against future viral outbreaks.
• CoViNet will also play a pivotal role in building and supporting laboratory capacities in low- and middle-income countries to monitor MERS-CoV and other emerging coronaviruses of public health importance.
  • By fostering knowledge exchange and capacity building, CoViNet aims to strengthen the global response to coronavirus threats.
• Furthermore, data generated through CoViNet's efforts will guide the work of the WHO's Technical Advisory Groups on Viral Evolution (TAG-VE) and Vaccine Composition (TAG-CO-VAC). These groups rely on cutting-edge research and surveillance data to inform public health policies and vaccination strategies.
• With 36 laboratories from 21 countries across all six WHO regions, CoViNet currently encompasses a wide range of expertise and resources.
  • Three Indian institutions, namely, the Council of Scientific and Industrial Research-National Environmental Engineering Research Institute, the Indian Council of Medical Research-National Institute of Virology in Pune, and the Translational Health Science and Technology Institute, proudly represent the country in this global network dedicated to coronavirus surveillance and preparedness.

About the World Health Organization (WHO):

• The World Health Organization (WHO) stands as a paramount global health authority, dedicated to promoting health, preventing diseases, and improving healthcare systems worldwide.
• Established in 1948, WHO operates as a specialized agency of the United Nations, with its headquarters in Geneva, Switzerland.
• It collaborates with governments, international organizations, and civil society to address pressing health challenges and provide guidance and support to countries in need.
• WHO's mandate encompasses a wide array of health-related issues, including infectious diseases, non-communicable diseases, mental health, maternal and child health, and environmental health.
• Through research, policy development, and technical assistance, WHO plays a vital role in shaping health policies, setting standards, and coordinating responses to health emergencies such as pandemics and natural disasters.
• With a mission to ensure the highest attainable level of health for all people, WHO continues to lead efforts in global health governance, advocacy, and capacity-building, striving for a healthier, safer, and more equitable world.

Why is it in the News?

Public knowledge and awareness about Hepatitis B, a deadly disease that can cause end-stage liver cirrhosis and liver cancer, is dismal in India, according to a new study conducted by Sir Ganga Ram Hospital, New Delhi.

What is Hepatitis B?

• It is a severe liver infection that can lead to liver damage, cancer, and death.
• The virus spreads through contact with an infected person's blood or bodily fluids.
• One can get hepatitis B through sexual contact, sharing needles or other drug-injection equipment, or from mother to child during childbirth.

Symptoms of Hepatitis B:

• Hepatitis B is a severe viral infection of the liver that can cause inflammation and scarring.
• Symptoms include fatigue, fever, abdominal pain, dark urine, joint pain, and jaundice.

Causes of Hepatitis B:

• Hepatitis B is caused by the hepatitis B virus (HBV).
• HBV is found in the blood and body fluids of an infected person. It can spread through contact with fluids, such as:
  • Blood, through needle sharing or accidental needle sticks
  • Contact with body fluids, such as saliva, etc.
  • Sexual contact with someone who has HBV
  • From a mother to a child through childbirth
• Hepatitis B can also spread through contact with contaminated surfaces, such as:
  • Sharing personal items like toothbrushes or razors with someone who has HBV
  • Getting a tattoo or body piercing with contaminated equipment

Types of Hepatitis B:

• There are three main types of hepatitis B: acute, chronic, and carriers.
  • Acute hepatitis B is a short-term illness that occurs within the first six months after exposure to the virus. It is the most common type of hepatitis B in children.
  • Chronic hepatitis B is a long-term illness that can lead to serious health problems, including liver failure and liver cancer.
  • Carriers of hepatitis B have the virus in their blood but do not show any symptoms.

Treatment for Hepatitis B

• Several medications can help treat hepatitis B.
• These include antiviral drugs, which can help reduce the amount of virus in the body, and immunomodulators, which can help boost the immune system to better fight the virus.
• If the liver is damaged, one may also need medication to help protect it from further damage.
• HBIG (Hepatitis B Immuno Globulin) is one of the best ways to treat hepatitis B.
  • Adults who have been exposed to hepatitis should get HBIG and vaccination as soon as possible, preferably within 24 hours but not later than 14 days after the exposure.

Prevention of Hepatitis B:

• The best way to prevent hepatitis B is to get vaccinated.
• The vaccine is given as a series of shots.
• The first shot is usually given at birth; the rest at 1–2 months old, 6–18 months old, and 4–6 years old.
• If one was not vaccinated as a child, they can receive the vaccines as an adult.

Why is it in the News?

Achieving one of the three priority areas agreed upon during India’s G20 presidency in 2023, the World Health Organization (WHO) recently launched the Global Initiative on Digital Health (GIDH) virtually, a platform for sharing knowledge and digital products among countries.

About Global Initiative on Digital Health (GIDH):

• The Global Initiative on Digital Health (GIDH) is a network managed by the World Health Organization (WHO), dedicated to enhancing and coordinating efforts for country-led digital health transformation through collaborative partnerships and knowledge sharing.
  • It was launched by the WHO and the Government of India during the G20 Health Ministerial Meeting in Gandhinagar.
• Functioning as a platform for inter-country knowledge exchange and digital product dissemination, GIDH strives to achieve several key objectives through collective action:
  • Assess and prioritise countries' requirements for sustainable digital health transformation.
  • Enhance the alignment of digital health resources and address unfunded priorities at the country level.
  • Facilitate the accelerated attainment of the strategic objectives outlined in the Global Strategy on Digital Health 2020-2025.
  • Promote capacity building and synergize efforts to support local development, maintenance, and adaptation of digital health technologies to evolving needs.
• Comprising four primary components, GIDH operates as a network of networks:
  • Country Needs Tracker: Tracks and prioritises country-specific digital health requirements.
  • Country Resource Portal: Provides a comprehensive map of available digital health resources within each country.
  • Transformation Toolbox: Shares quality-assured digital tools to support country-led digital health initiatives.
  • Knowledge Exchange: Facilitates the exchange of insights and best practices among member countries.
• GIDH extends support to countries in three fundamental ways:
  • By attentively addressing their needs
  • By fostering resource alignment to prevent fragmentation, and
  • By offering access to quality-assured digital products.
• Membership in GIDH is open to all institutions actively involved in the digital health domain.

What is Digital Health?

• Digital health denotes the utilisation of technology, encompassing mobile devices, software applications, and various digital tools, to enhance health outcomes and streamline healthcare delivery.
• Essentially, it represents an interdisciplinary field at the intersection of technology and healthcare, integrating a diverse array of concepts and innovations.
• This encompasses a broad spectrum of technologies and services, spanning telemedicine, electronic health records, wearable devices, health information exchange, and more.
• Examples of notable digital health initiatives include India’s CoWIN platform and UNICEF's RapidPro and FamilyConnect programs.
• RapidPro, UNICEF’s real-time information platform, serves as a foundational component in its digital health portfolio.
• FamilyConnect, another UNICEF initiative, delivers targeted, lifecycle-based messages via SMS to various recipients, including pregnant women, new mothers, and heads of households.

India Initiatives on Digital Health:

• National Digital Health Mission (NDHM): Designed to establish a comprehensive national digital health ecosystem featuring unique health IDs, electronic health records (EHRs), and a platform for health data exchange.
• Ayushman Bharat Digital Mission (ABDM): Aims to develop a digital infrastructure for the Ayushman Bharat Health Infrastructure Mission (ABHIM), incorporating health registries, electronic claim processing, and telemedicine services.
• E-Sanjeevani Telemedicine Platform: Enables virtual consultations between healthcare providers and patients nationwide, enhancing access to medical care.
• Jan Arogya Setu App and CoWIN Platform: Offers access to healthcare services, facilitates appointment scheduling, and disseminates COVID-19-related information.
• Digital Aarogya Mitra (DAM): Implements a community health worker program utilising technology for data collection and community-based health interventions.

Why in the News?

The World Health Organization (WHO) has announced that Guinea's Health Ministry has officially notified them of a diphtheria outbreak.

What is Diphtheria?

• Diphtheria, an extremely contagious and infectious disease, instigates severe inflammation in the nose, throat, and trachea (windpipe).
• This ailment is caused by strains of bacteria known as Corynebacterium diphtheriae, which produce a potent toxin responsible for the onset of illness.

Causes:

• The bacterial infection spreads through various means, including respiratory droplets emitted during coughing or sneezing.
• Transmission can also occur through contact with infected open sores or ulcers. The bacteria's toxin is the primary culprit behind the illness.

Symptoms:

• Manifesting 2-5 days post-infection, symptoms of diphtheria encompass a thick, grey membrane covering the throat and tonsils, a sore throat, hoarseness, swollen glands in the neck, difficulty breathing, nasal discharge, fever, chills, and fatigue.
• If the toxin enters the bloodstream, it can lead to damage to the heart, nerves, and kidneys.

Infection and Spread:

• Diphtheria bacteria thrive on person-to-person transmission, emphasizing respiratory droplets as a common mode of contagion.
• Skin infections are possible but seldom result in severe disease.

Treatment:

• Combatting diphtheria involves a dual-pronged approach:
• Antitoxin (Anti-diphtheritic Serum): This neutralizes bacterial toxins and is specifically employed for respiratory system infections. The antitoxin acts on toxins that haven't bound with cells and tissues.
• Antibiotics (Erythromycin or Penicillin): These medications eradicate the bacteria, preventing further spread. Antibiotics are effective against both the respiratory system and skin infections caused by diphtheria.

Why is it in the News?

Union Health Minister Dr Mansukh Mandaviya has launched MedTech Mitra - a strategic initiative to empower MedTech innovators and advance healthcare solutions.

What is the MedTech Mitra Portal?

• The MedTech Mitra portal is an online platform designed to support medtech innovators by assisting in clinical evaluation, regulatory facilitation, and the adoption of new products in the medical technology sector.
• This collaborative initiative is overseen by the Indian Council of Medical Research (ICMR) and the Central Drugs Standard Control Organisation (CDSCO), operating under the direction/guidance of NITI Aayog’s Atal Innovation Mission.

Significance:

• In conjunction with recent policies and incentive schemes, such as the medical devices policy and the production-linked incentive scheme, the MedTech Mitra platform aims to catalyze growth in the medical devices sector and promote domestic manufacturing.
• These initiatives seek to foster the indigenous development of affordable and high-quality MedTech devices and diagnostics, thereby significantly reducing the sector's reliance on imports.
• The platform is envisioned to streamline the innovation process and facilitate research and development for emerging start-ups, ensuring a smoother journey from concept to product.
• By offering comprehensive guidance, including support for animal and clinical trials, the platform aims to bridge gaps for startups and promote ease of innovation.
• The MedTech Mitra portal is poised to foster collaborations between engineers, scientists, and clinicians, addressing a previously existing gap in partnerships within the sector.

About the Indian Council of Medical Research (ICMR):

• The Indian Council of Medical Research (ICMR) serves as the apex institution in India responsible for formulating, coordinating, and advancing biomedical research.
• With a primary mandate to conduct, coordinate, and implement medical research for societal benefit, ICMR is dedicated to translating medical innovations into tangible products and processes, subsequently integrating them into the public health system.
• Financial support for ICMR is provided by the Government of India through the Department of Health Research, Ministry of Health & Family Welfare.

Why in the News?

The National Health Authority (NHA) has recently declared the extension of its Digital Health Incentives Scheme (DHIS) until the 31st of December 2023.

About Digital Health Incentives Scheme (DHIS):

• Launched in December 2022, the DHIS became effective from 1st January 2023.
• The scheme is implemented by the National Health Authority (NHA) under the Ministry of Health and Family Welfare.
• Its primary objectives include giving a further impetus to digital health transactions across the country through the Ayushman Bharat Digital Mission (ABDM).

Salient Features of DHIS:

• The scheme offers incentives of up to four crore rupees, determined by the number of digital health records created and linked to patients' Ayushman Bharat Health Account numbers.
• Incentives are extended to hospitals, diagnostic labs, and providers of digital health solutions, including Hospital/Health Management Information Systems (HMIS) and Laboratory Management Information Systems (LMIS).
• Health facilities (hospitals and diagnostic labs) registered with the Ayushman Bharat Digital Mission's Health Facility Registry (HFR) and meeting the specified eligibility criteria can avail of the incentives.

Benefits of DHIS:

• Incentives for Digitization: Healthcare facilities and Digital Solution Companies participating in the scheme can earn incentives to cover expenses related to digitization.
• Enhanced Efficiency in Healthcare Delivery: DHIS streamlines the healthcare process, eliminating hassles in registration, appointment scheduling, consultations, IPD admission, discharge, and more.
• Robust Digital Health Ecosystem: The scheme contributes to the development of a strong digital health ecosystem, encompassing various levels of healthcare facilities.
• Improved Quality of Care: DHIS facilitates evidence-based, accessible, and high-quality healthcare services, leading to better patient outcomes and satisfaction.

Why in the News?

Scientists at the Indian Institute of Science's Materials Research Centre (MRC) have recently created a novel enzyme mimic known as NanoPtA.

About NanoPtA:

• The research team at the Materials Research Centre (MRC), Indian Institute of Science (IISc), has created a unique platinum-based nanozyme called NanoPtA.
• This nanozyme can be turned into a powder for use in industries.                                                                                                                                                                                                        
• When NanoPtA encounters wastewater, the molecule's benzene rings and long alkyl chains engage in multiple non-covalent interactions.
• Individual NanoPtA molecules link together to form tape-like structures that emit light, which is the source of its oxidizing capability.
• In the presence of sunlight, this nanozyme can break down pollutants in wastewater, reducing its toxicity.
• Remarkably, the nanozyme can rapidly degrade even small amounts of common contaminants like phenols and dyes (micromolar levels) within ten minutes when exposed to sunlight.
• The researchers also observed that the NanoPtA complex remained stable for up to 75 days at room temperature.

Applications:

• Besides wastewater treatment, this nanozyme could find applications in healthcare and serve as a valuable diagnostic tool for neurological and neurodegenerative diseases.